Understanding Mammalian Locomotion

Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.

A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: * The structure, regulation and expression of the AP genes * The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes * The phenotypic abnormalities of the different AP knockout mice * Our current understanding of the in vivo role of the AP isozymes. The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzymes in clinical medicine and in biotechnology.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

This book brings together contributions from key investigators in the area of Transient Receptor Potential (TRP) channel structure and function. It covers the structure, function and regulation of mammalian TRP channels and mechanisms of signal transduction. The discussions indicate research that would improve understanding of the role of TRP channels in normal cellular physiology, the involvement of TRP channels in disease states and their potential use as molecular targets for novel therapeutic agents.

There are many different types of explosions, each with its own complex mechanism. Understanding explosions is important in preventing them. This reference provides valuable information on explosions for everyone involved in the operation, design, maintenance, and management of chemical processes, helping enhance understanding of the nature of explosions and the practical methods required to prevent them from occurring. The text includes: Fundamental basis for explosions Explosive and flammable behavior and characteristics of materials Different types of explosions Fire and explosion hazard recognition Practical methods for preventing explosions or minimizing the potential consequences Additional references Understanding Explosions provides a practical understanding of explosion fundamentals, including the different types of explosions, the explosive and flammable behavior of materials, and the hazards related to fires and explosions. It also discusses practical methods to prevent and minimize the probability and consequence of an explosion during routine use of flammable, combustible and/or reactive materials.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Understanding Physics – Second edition is a comprehensive, yet compact, introductory physics textbook aimed at physics undergraduates and also at engineers and other scientists taking a general physics course. Written with today's students in mind, this text covers the core material required by an introductory course in a clear and refreshing way. A second colour is used throughout to enhance learning and understanding. Each topic is introduced from first principles so that the text is suitable for students without a prior background in physics. At the same time the book is designed to enable students to proceed easily to subsequent courses in physics and may be used to support such courses. Mathematical methods (in particular, calculus and vector analysis) are introduced within the text as the need arises and are presented in the context of the physical problems which they are used to analyse. Particular aims of the book are to demonstrate to students that the easiest, most concise and least ambiguous way to express and describe phenomena in physics is by using the language of mathematics and that, at this level, the total amount of mathematics required is neither large nor particularly demanding. 'Modern physics' topics (relativity and quantum mechanics) are introduced at an earlier stage than is usually found in introductory textbooks and are integrated with the more 'classical' material from which they have evolved. This book encourages students to develop an intuition for relativistic and quantum concepts at as early a stage as is practicable. The text takes a reflective approach towards the scientific method at all stages and, in keeping with the title of the text, emphasis is placed on understanding of, and insight into, the material presented.

Praise for the First Edition «…a reference for everyone who is interested in knowing and handling uncertainty.» —Journal of Applied Statistics The critically acclaimed First Edition of Understanding Uncertainty provided a study of uncertainty addressed to scholars in all fields, showing that uncertainty could be measured by probability, and that probability obeyed three basic rules that enabled uncertainty to be handled sensibly in everyday life. These ideas were extended to embrace the scientific method and to show how decisions, containing an uncertain element, could be rationally made. Featuring new material, the Revised Edition remains the go-to guide for uncertainty and decision making, providing further applications at an accessible level including: A critical study of transitivity, a basic concept in probability A discussion of how the failure of the financial sector to use the proper approach to uncertainty may have contributed to the recent recession A consideration of betting, showing that a bookmaker's odds are not expressions of probability Applications of the book’s thesis to statistics A demonstration that some techniques currently popular in statistics, like significance tests, may be unsound, even seriously misleading, because they violate the rules of probability Understanding Uncertainty, Revised Edition is ideal for students studying probability or statistics and for anyone interested in one of the most fascinating and vibrant fields of study in contemporary science and mathematics.

The first introductory palaeontology text which demonstrates the importance of selected fossil groups in geological and biological studies, particularly in understanding evolutionary patterns, palaeoenvironmental analysis, and stratigraphy. Part one explores several key concepts, such as the processes of fossil preservation, the determination of evolutionary patterns, and use of fossils and statigraphical tools. Part two introduces the main fossil groups of value in these applied fields. Part three concentrates on the examination of important case histories which demonstrate the use of fossils in diverse practical examples. Evolutionary studies, palaeoenvironmental analysis, and stratigraphical applications are documented using up-to-date examples supported by overviews of the principles.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.