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Alzheimer's Disease is an ever present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume provides a unique source of reference to the important work being done in this field, it gives academics and clinicians an opportunity to learn about cutting edge developments and covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.

THE encyclopedic guide to hepatology – for consultation by clinicians and basic scientists Previously the Oxford Textbook of Clinical Hepatology, this two-volume textbook is now with Blackwell Publishing. It covers basic, clinical and translational science (converting basic science discoveries into the practical applications to benefit people). Edited by ten leading experts in the liver and biliary tract and their diseases, along with outstanding contributions from over 200 international clinicians, this text has global references, evidence and extensive subject matter – giving you the best science and clinical practice discussed by the best authors. It includes unique sections on: Symptoms and signs in liver disease Industrial diseases affecting the liver The effects of diseases of other systems on the liver The effects of liver diseases on other systems It’s bigger and more extensive than other books and discusses new areas in more depth such as stem cells, genetics, genomics, proteomics, transplantation, mathematics and much more. Plus, it comes with a fully searchable CD ROM of the entire content. Click here to view a sample chapter on the liver and coagulation

The most comprehensive textbook in the field edited by the founding father of endourology returns for a new edition. In full colour throughout and packed with surgical teaching videos, this is an essential purchase for all urologists wishing to master their skills.

Brought to you by the world’s leading transplant clinicians, Textbook of Organ Transplantation provides a complete and comprehensive overview of modern transplantation in all its complexity, from basic science to gold-standard surgical techniques to post-operative care, and from likely outcomes to considerations for transplant program administration, bioethics and health policy. Beautifully produced in full color throughout, and with over 600 high-quality illustrations, it successfully: Provides a solid overview of what transplant clinicians/surgeons do, and with topics presented in an order that a clinician will encounter them. Presents a holistic look at transplantation, foregrounding the interrelationships between transplant team members and non-surgical clinicians in the subspecialties relevant to pre- and post-operative patient care, such as gastroenterology, nephrology, and cardiology. Offers a focused look at pediatric transplantation, and identifies the ways in which it significantly differs from transplantation in adults. Includes coverage of essential non-clinical topics such as transplant program management and administration; research design and data collection; transplant policy and bioethical issues. Textbook of Organ Transplantation is the market-leading and definitive transplantation reference work, and essential reading for all transplant surgeons, transplant clinicians, program administrators, basic and clinical investigators and any other members of the transplantation team responsible for the clinical management or scientific study of transplant patients.

Now in its Fifth Edition, Crofton and Douglas's Respiratory Diseases has firmly established itself as the leading clinical textbook on diseases of the chest. Presented, for the first time, as a two-volume set, this classic text has been completely rewritten and greatly expanded. Extensive revisions ensure that these volumes present an up-to-date review of all aspects of lung disease . The contributions of some 18 leading authorities ensure that each area is comprehensively covered and new to this edition are chapters on the genetics of lung disease, smoking, air pollution, sleep apnoea, diving, lung transplantation and medico-legal aspects. The changes in content reflect the pace of change in the areas concerned not only in terms of understanding of the disease processes but also their treatment. The single chapter on asthma that appeared in previous editions, has now been expanded into three chapters covering epidemiology, mechanisms and management, reflecting the enormous research effort currently underway following a marked increase in the incidence of this disease in recent years. This new edition continues to provide an excellent reference both for the trainee and specialist in respiratory medicine, as well as the general physician. It will be extremely useful on the ward and in the office, where clinical problems arise and questions are asked which need clear answers.

The Second Edition of Connective Tissue and Its Heritable Disorders: Molecular, Genetic, and Medical Aspects is the definitive reference text in its field, with over 40% more pages on the nature, diagnosis, and treatment of disease than its predecessor. Collecting new research on disorders detailed in the first edition as well as on those previously excluded, editors Peter Royce and Beat Steinmann provide the most up-to-date clinical and scientific information for medical specialists treating affected individuals. Features of this revised and updated volume include detailed reviews of the clinical diagnosis, mode of inheritance, risk of recurrence, and prenatal diagnosis of each inherited connective tissue disorder; a thorough description of the morphology of connective tissues; a completely updated and revised section on the biology of the extracellular matrix; and the addition of syndromes such as craniosyntosis, and disorders of sulfate metabolism.

The third edition of this highly regarded text continues to provide a comprehensive resource for pediatric dermatologists. The book offers evidence-based diagnosis and treatment recommendations and covers both common and rare conditions, including emerging conditions and research, especially at the genetic level. A refreshing new text design makes the book more accessible, and new editors and contributors bring a distinctly international perspective to the work.

Cost-effective manufacturing of biopharmaceutical products is rapidly gaining in importance, while healthcare systems across the globe are looking to contain costs and improve efficiency. To adapt to these changes, industries need to review and streamline their manufacturing processes. This two volume handbook systematically addresses the key steps and challenges in the production process and provides valuable information for medium to large scale producers of biopharmaceuticals. It is divided into seven major parts: – Upstream Technologies – Protein Recovery – Advances in Process Development – Analytical Technologies – Quality Control – Process Design and Management – Changing Face of Processing With contributions by around 40 experts from academia as well as small and large biopharmaceutical companies, this unique handbook is full of first-hand knowledge on how to produce biopharmaceuticals in a cost-effective and quality-controlled manner.

The only international clinical textbook for COPD – one of the top 5 causes of death and disability worldwide The only COPD textbook to include the latest national and international guidelines and the newer therapeutic agents in COPD treatment International team of contributors covers all aspects of COPD – from physiology and epidemiology to diagnosis and treatment Everything the busy physician needs to understand, diagnose and treat the COPD patient: – Structure and physiology of the respiratory system – Clinical considerations and allied conditions – Therapy (including current and developing treatments) – Diagnostic tests used in daily practice

The rapidly growing population of adults surviving with congenital heart lesions along with the success of interventional cardiology in the child and adolescent has spawned an incredible interest in adapting the technology for the adult congenital patients. Dr. Mullins, a pioneer in this area, has written an outstanding reference which covers all aspects of performing diagnostic and therapeutic cardiac catheterization procedures on patients of all ages. This illustrated book details the equipment and techniques for performing safe and successful procedures, with a strong emphasis on avoiding complications. It also includes the requirements of a catheterization laboratory for congenital heart patients, as well as guidance for setting up and operating such a laboratory. Cardiac Catheterization in Congenital Heart Disease serves as an essential manual for pediatric and adult interventional cardiologists worldwide.

The definitive guide to the science, diagnosis and treatment of all known nail diseases The fifth edition of Baran & Dawber’s Diseases of the Nails and their Management continues to offer an encyclopedic account of the human nail that is unparalleled in its detail and scope. With contributions from some of the world’s leading dermatologists, the book’s exhaustive coverage encompasses the cosmetic and therapeutic management of every form of nail disease. High-quality images and diagrams illustrate and enhance this essential reference guide, while easy-to-navigate sub-chapters help you to find the information you need quickly and accurately. This book: Is edited by Professor Robert Baran – the world’s leading expert on the human nail – together with a team of world-renowned experts from across Europe and North America Provides clinical information on all nail diseases Aids differential diagnosis by color, shape, and location Contains over 1,500 images Includes access to a companion website featuring downloadable images and videos of nail procedures Whether they are new to the field or have been practicing for years, dermatologists, podiatrists, and all of those managing patients with nail diseases should have a copy of Baran & Dawber’s Diseases of the Nails and their Management at their disposal.

Rutter’s Child and Adolescent Psychiatry has become an established and accepted textbook of child psychiatry. Now completely revised and updated, the fifth edition provides a coherent appraisal of the current state of the field to help trainee and practising clinicians in their daily work. It is distinctive in being both interdisciplinary and international, in its integration of science and clinical practice, and in its practical discussion of how researchers and practitioners need to think about conflicting or uncertain findings. This new edition now offers an entirely new section on conceptual approaches, and several new chapters, including: neurochemistry and basic pharmacology brain imaging health economics psychopathology in refugees and asylum seekers bipolar disorder attachment disorders statistical methods for clinicians This leading textbook provides an accurate and comprehensive account of current knowledge, through the integration of empirical findings with clinical experience and practice, and is essential reading for professionals working in the field of child and adolescent mental health, and clinicians working in general practice and community pediatric settings.

Biomechanics in Sport is a unique reference text prepared by the leading world experts in sport biomechanics. Over thirty chapters cover a broad spectrum of topics, ranging from muscle mechanics to injury prevention, and from aerial movement to wheelchair sport. The biomechanics of sports including running, skating, skiing, swimming, jumping in athletics, figure skating, ski jumping, diving, javelin and hammer throwing, shot putting, and striking movements are all explained.

The aim of this book has always been to give guidance on the diagnosis and treatment of ocular motility disorders based on clinical experience, as opposed to a comprehensive treatise on the subject drawn from the primary literature. The Third Edition sees a new team of authors who have kept very much to this priniciple in their nevertheless thorough revision of the book. Whilst there are no new chapters as such, the immediate impact of the revision is in the improved page layout with increased use of diagrams and flowcharts. There are new sections on feigned visual loss in adults and children, the management of residual defects and the section on botulinum toxin treatment in chapter 8 will be re-written to take account of the great advances in this form of treatment.

Provides coverage of the pathogenesis, clinical, morphologic, molecular and investigational aspects of a full range of blood disorders seen in daily practice The revised fifth edition of this renowned atlas presents readers with a comprehensive, visual guide to clinical hematology, featuring 2700 full-color photographs and figures depicting the spectrum of hematological diseases. Ranging from photographs of the clinical manifestations and key microscopic findings to diagrams of the molecular aspects of these diseases, the book provides up-to-date information of the blood diseases that clinicians encounter every day. Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease offers the reader an understanding of normal cell machinery, and of the molecular basis for such processes as DNA and cell replication, RNA species, trafficking and splicing, protein synthesis, transcription factors, growth factor signal transduction, epigenetics, cell differentiation, autophagy, and apoptosis. The text goes on to explore how these processes are disturbed in the various diseases of the bone marrow, blood, and lymphoid systems. Helps solve difficult diagnostic challenges and covers complex principles using highly illustrative, full-color images Explores all aspects of benign and malignant hematology, including blood transfusion and coagulation with extensive coverage of the pathogenesis of common clinical entities Provides a quick and easy reference of key diagnostic issues in a comprehensive yet concise format Includes and illustrates the WHO Classification of Hematologic Malignancies Illustrates the new knowledge of the molecular basis of inherited and acquired blood diseases Color Atlas of Clinical Hematology: Molecular and Cellular Basis of Disease is the must-have resource for both trainee and practising hematologists, and for every department of hematology.

The renowned Principles and Practice of Geriatric Psychiatry, now in its third edition, addresses the social and biological concepts of geriatric mental health from an international perspective. Featuring contributions by distinguished authors from around the world, the book offers a distinctive angle on issues in this continually developing discipline. Principles and Practice of Geriatric Psychiatry provides a comprehensive review of: geriatric psychiatry spanning both psychiatric and non-psychiatric disorders scientific advances in service development specific clinical dilemmas New chapters on: genetics of aging somatoform disorders epidemiology of substance abuse somatoform disorders care of the dying patient Continuing the practice of earlier editions, the major sections of the book address aging, diagnosis and assessment and clinical conditions, incorporating an engaging discussion on substance abuse and schizophrenic disorders. Shorter sections include the presentation of mental illness in elderly people from different cultures—one of the most popular sections in previous editions. Learning and behavioural studies, as well as models of geriatric psychiatry practice, are covered extensively. This book provides a detailed overview of the entire range of mental illness in old age, presented within an accessible format. Principles and Practice of Geriatric Psychiatry is an essential read for psychiatrists, geriatricians, neurologists and psychologists. It is of particular use for instructors of general psychiatry programs and their residents.

Textbook and Color Atlas of Traumatic Injuries to the Teeth, Fifth Edition encompasses the full scope of acute dental trauma, including all aspects of interdisciplinary treatment. New edition of the definitive reference on dental traumatology Thoroughly revised and updated with a modern look and feel Eight new chapters on innovative developments in the field Contributions from world-renowned authors and editors Linked to dentaltraumaguide.org with a specific chapter on how the book complements the online guide

This is the first book to address all aspects of the biology of autoantibodies in a single volume, including a discussion of immunology, experimental models, clinical aspects, and the use of autoantibodies as probes in molecular and cellular biology. The editor, currently professor at the W.M. Keck Autoimmune Disease Center of The Scripps Research Institute, has assembled an all-star team of authors to report on the latest research, technologies, and applications. Following an introductory chapter, the book goes on to cover such topics as cellular mechanisms of autoantibody production, clinical and diagnostic usefulness in human disease, and animal models used to study the elicitation of autoantibodies. The whole is rounded off with a look at future perspectives. With its comprehensive coverage, this volume will appeal not only to immunologists and clinicians but also to cell and molecular biologists.

This exciting and important book covers the impact on demography of the nutrition of populations, offering the view that the change from the hunter-gatherer to an agricultural life-style had a major impact on human demography, which still has repercussions today. Demography and Nutrition takes an interdisciplinary approach, involving time-series analyses, mathematical modelling, aggregative analysis and family reconstitution as well as analysis of data series from Third World countries in the 20th Century. Contents include details and analysis of mortality oscillations, food supplies, famines, fertility and pregnancy, infancy and infant mortality, ageing, infectious diseases, and population dynamics. The authors, both well known internationally for their work in these areas, have a great deal of experience of population data gathering and analysis. Within the book, they develop the thesis that malnutrition, from which the bulk of the population suffered, was the major factor that regulated demography in historical times, its controlling effect operated via the mother before, during and after pregnancy. Demography and Nutrition contains a vast wealth of fascinating and vital information and as such is essential reading for a wide range of health professionals including nutritionists, dietitians, public health and community workers. Historians, social scientists, geographers and all those involved in work on demography will find this book to be of great use and interest. Libraries in all university departments, medical schools and research establishments should have copies of this landmark publication available on their shelves.

There has been very little written on the interaction of the liver and kidney. This book addresses the increasing incidence and significance of diseases, such as ascites, renal dysfunction, cirrhosis and hypertension where both organs are involved. This textbook is essential, even for confirmed practitioners and contains current information regarding treatment and therapy for patients with cirrhosis and ascites, clearly and effectively presented by the top international experts within this field. The second edition is entirely revised and updated and places greater emphasis on therapy.

The relationship of metabolic diseases to cardiovascular disease (CVD) is reaching epidemic proportions. This relates mostly to the increasing prevalence of obesity, the metabolic syndrome and type 2 diabetes. This book outlines and addresses the metabolic factors and related diseases that contribute to CVD, including brief introductions to metabolic pathways including lipid and lipoprotein metabolism, macronutrient fuel partitioning, insulin action and body weight regulation. Mechanisms that relate to becoming obese, maintenance of the obese state, the dyslipidemias, and glucose intolerance/diabetes are also addressed, and the importance of interventions that reduce metabolic risk factors and CVD are covered.

Coercion is one of the most fascinating and controversial subjects in psychiatry. It is a highly sensitive, and hotly debated topic in which clinical practice, ethics, the law and public policy converge. This book considers coercion within the healing and ethical framework of therapeutic relationships and partnerships at all levels, and addresses the universal problem of how to balance safety versus autonomy when dealing with psychiatric treatment. Coercive Treatment in Psychiatry is a much needed contribution to the literature. The first three sections deal with the conceptual and clinical aspects of coercive treatment, the legal aspects and the ethical aspects of coercive treatment. In detail, these sections cover a broad spectrum of issues: coercion in institutions and in the community, coercive treatment and stigma, the definition of best practice standards for coercive treatment, de-escalation of risk situations, recent developments in mental health legislation, mental health care and patients' rights, cross-cultural perspectives on coercive treatment, historical injustice in psychiatry, and paternalism in mental health. The fourth section features users' views on coercive treatment: giving voice to an often-unheeded population. Finally, the book addresses the original topic of coercion and undue influence in decisions to participate in psychiatric research. This book presents the first comprehensive review of the issue of coercion in psychiatry. With chapters written by the leading experts in the field, many of whom are renowned as clear thinkers and experienced clinicians, it may be seen as a starting point for international discussions and initiatives in this field aiming to minimize coercion. Highly Commended in the Psychiatry section of the 2012 BMA Book Awards.

BACE inhibitors and their use in the treatment of Alzheimer's Disease BACE (β-site of APP cleaving enzyme) is a critical component in Alzheimer's Disease (AD), and the development of BACE inhibitors shows great potential as a therapy for the disease. BACE: Lead Target for Orchestrated Therapy of Alzheimer's Disease covers virtually all aspects of BACE from initial identification, discovery of inhibitors, and challenges in clinical development, while providing a global understanding essential for productive and successful drug discovery. This book details the story of the discovery of BACE and its role in AD and comprehensively discusses: The development of BACE inhibitors as therapeutics for Alzheimer's disease The research that led to the identification of BACE New BACE inhibitors currently being clinically tested ADME (absorption, distribution, metabolism, excretion) and clinical trial design—topics not addressed in current field literature Cutting-edge technology such as high-throughput screening, structure-based drug design, and QSAR in context of BACE inhibitors and Alzheimer's drug discovery Other approaches to BACE inhibition based on interaction with the precursor protein APP By enhancing the reader's understanding of the various aspects of the BACE drug-discovery process, this much-needed reference will serve as a key resource for all scientists involved in Alzheimer's research—and inspire new approaches to treatment of AD.

Dental Management of Sleep Disorders focuses on the dentist’s role in treating patients with sleep problems, chiefly sleep disordered breathing and bruxism. A practical clinical book, Dental Management of Sleep Disorders highlights the background to these problems, discusses the dentist’s role in their diagnosis and treatment, and outlines clinical strategies and guidance. The book features a full discussion of the use of appliances, an overview of current treatment modalities, and investigates the relationship of sleep disorders to dental and orofacial causes.

Cancer Prevention and Screening offers physicians and all clinical healthcare professionals a comprehensive, useful source of the latest information on cancer screening and prevention with both a global and a multidisciplinary perspective. Includes background information on epidemiology, cancer prevention, and cancer screening, for quick reference Offers the latest information for clinical application of the most recent techniques in prevention and screening of all major and many lesser cancer types Emphasises the importance of multidisciplinary teamwork in cancer screening Highlights frequent dilemmas and difficulties encountered during cancer screening Provides clear-cut clinical strategies for optimal patient education, communication, and compliance with cancer prevention techniques

Two key challenges face mental health practitioners: making the correct psychiatric diagnosis and choosing the most appropriate treatment option. This book aims to help with both. Clinical Guide to the Diagnosis and Treatment of Mental Disorders – Second Edition combines clinically-relevant information about each of theDSM-IV-TR diagnoses with clear, detailed information on treatment options, giving full clinical management advice. Once again, the editors, both leading psychiatrists, have condensed the chapters on Disorders from Tasman et al’s acclaimed two volume textbook of Psychiatry (now in its Third Edition), retaining only the content they deem particularly relevant to the clinician for ease of use. Each disorder is discussed under the headings of Diagnosis (including Assessment Issues, Comorbidity, Course, and Differential Diagnosis, giving diagnostic decision trees where relevant) and Treatment (listing all therapeutic options, giving practical advice for patient management, summarising treatment specifics with tables and treatment flowcharts). The original edition established itself as the first point of reference for any clinician or mental health practitioner needing expert advice on therapeutic options for any psychiatric disorder. This edition features an additional chapter on the psychiatric interview and assessment of mental status to increase its utility. It echoes the progress in psychiatry regarding the establishment of an evidenced-based model of taxonomy, diagnosis, etiology, and treatment. Indeed, from a psychologist's perspective, the equal consideration provided to empirically supported psychosocial treatments versus somatic treatment is a significant development in the field of psychiatry. Jonathan Weinand in PsycCritiques, the American Psychological Association Review of Books

This book fulfils an urgent need for an updated text on pediatric psychopharmacology. It takes a unique approach in discussing recent findings within the context of current issues, including economic and political ones. The book covers the emerging question of treating children who do not yet meet diagnostic criteria for psychosis, e.g, schizophrenia or bipolar disorder, but who are deemed to be at high risk. This is an active area of debate: such children are being treated in certain centers, while others reject this completely. The book addresses the antidepressant controversy, the placebo response and unique strategies for delineating this, and ways to optimize the differential between active medication and placebo. It reviews the impact of recent American Heart Association guidelines for monitoring children on stimulants and other psychotropics. It adheres closely to DSM-IV diagnostic criteria throughout. The book describes the use of newly approved drugs such as Lexapro for treating adolescent depression and the novel compound Intuniv. It covers the TADS and CAMS studies, which evaluated the use of SSRIs alone and in combination with cognitive behavioral therapy for adolescent depression. Other topics include treatment of bipolar disorders, the increasing popularity of generic equivalents, combination pharmacotherapy and the potential dangers of psychotropic medications. Third edition of the first ever book published on pediatric psychopharmacology from renowned editors. Incorporates current developments with regard to SSRIs, their indications and their safety issues, including possible associated suicidal behavior. Addresses concerns about cardiovascular side effects of the new stimulant medications available, and compares to other FDA-approved medications for ADHD. Features many tables, figures and pictorials, making it highly accessible and reader friendly.

This book forms part of a series entitled Promoting Partnership for Health published in association with the UK Centre for the Advancement of Interprofessional Education (CAIPE). The series explores partnership for health from policy, practice and educational perspectives. Whilst strongly advocating the imperative driving collaboration in healthcare, it adopts a pragmatic approach. Far from being starry eyed, the series alerts readers to the pitfalls and ways to avoid them. ____________________________________________________________________________________ International Perspectives on Health and Social Care adopts a thematic approach to health and social care partnerships. The book offers workable information on key topics such as integrated service models, partnership working and finance, self-management and the co-ordination of services, individual budgets, managing integration and working across the health and social care boundary. The importance of inter-professional practice is emphasised throughout with a key chapter that explores the knowledge, attitudes and skills required by practitioners from different professional backgrounds in order to work together collaboratively. With chapters by leading international commentators, the book explores key terms and approaches to partnership working, helping readers to consider which way of working may be appropriate for which types of outcomes.

What types of mental health care are right for the 21st century—in all countries, around the world? What is the best balance of primary care and specialist mental health care for people with mental illness? What is the best evidence for effective treatments and services? Which methods are most suitable for answering these questions? These are the tough issues addressed by this book. Leading experts from across the world bring their experience to bear in a series of chapters that set out the very best evidence in this field. They present clear accounts of what is known, extensively referenced, with critical appraisals of the strength of the evidence and the robustness of the conclusions that can be drawn. This book was inspired by the work of Michele Tansella on the development of community care globally. It comprises four sections, identifying the challenges associated with providing mental health services in high-, middle- and low-income countries, then describing ways to meet these challenges. A section on new research methods to produce practical evidence is a novel aspect of the book. The final section addresses how best to deliver new forms of care, bearing in mind the human resources available. The chapters extensively cite specific studies to enhance the practical relevance. Much of the cited research involves service users so their voice is heard throughout the text. Mental health is rapidly becoming recognised as one of the leading global health challenges. This book adds to our knowledge of the challenge and the solutions and stands to make a significant contribution to global mental health.

This clinical manual provides a CBT-based psychosocial intervention for use with individuals distressed about their appearance due to a disfigurement from birth, accident or illness, or those coping with another visible difference. Contains a wealth of case material with specific relevance to physical health conditions that affect appearance, practical advice on assessment, and session-by-session guidance for addressing common issues Written by leading academics and clinicians working in the management of disfigurement and rational appearance anxiety Uses a flexible stepped-care model that allows for use by experienced CBT practitioners as well those wishing to deliver a more basic psychological intervention Identifies the psychological factors involved in appearance anxiety while also addressing the practical concerns of living with a visible difference, such as managing the reactions of others

This book describes clearly how legislation can be used to advance the rights and entitlements of people with mental health problems. Straightforward and practical, it provides useful information on how to address disabilities so these people may enjoy full citizenship. It presents the key issues succinctly and illustrates these with legislative examples from around the world. This book documents the role that law can play, at all levels, in combating such discrimination and abuse.

This book provides a practical guide to analysis of simple and complex method comparison data, using Stata, SAS and R. It takes the classical Limits of Agreement as a starting point, and presents it in a proper statistical framework. The model serves as a reference for reporting sources of variation and for providing conversion equations and plots between methods for practical use, including prediction uncertainty. Presents a modeling framework for analysis of data and reporting of results from comparing measurements from different clinical centers and/or different methods. Provides the practical tools for analyzing method comparison studies along with guidance on what to report and how to plan comparison studies and advice on appropriate software. Illustrated throughout with computer examples in R. Supported by a supplementary website hosting an R-package that performs the major part of the analyses needed in the area. Examples in SAS and Stata for the most common situations are also provided. Written by an acknowledged expert on the subject, with a long standing experience as a biostatistician in a clinical environment and a track record of delivering training on the subject. Biostatisticians, clinicians, medical researchers and practitioners involved in research and analysis of measurement methods and laboratory investigations will benefit from this book. Students of statistics, biostatistics, and the chemical sciences will also find this book useful.

Dentistry has been undergoing enormous changes, and the field of endodontics has certainly been at the forefront. Recent advances in technology, materials, and equipment have changed the way endodontics is practiced today, thereby facilitating treatments with greater efficiency, precision, and success, ultimately leading to better outcomes. Current Therapy in Endodontics encompasses the recent discoveries and applications for this field in one clinically relevant volume. Evidence-based presentation of recent advances in the field of endodontics Objective comparison of materials and instruments on the market Tables present key data and instruction for quick viewing and comprehension

Since 1960, the burden of adolescent illness has shifted from the traditional causes of disease to the more behavior-related problems, such as drinking, smoking and drug abuse (nearly half of American adolescents have used an illicit drug sometime during their life). Instilling in adolescents the knowledge, skills, and values that foster physical and mental health will require substantial changes in the way health professionals work and the way they connect with families, schools, and community organizations. At the same time, the major textbooks on addiction medicine and addiction psychiatry devote relatively little attention to the special problems of diagnosing and treating adolescent addicts. Similarly, the major textbooks on general and child and adolescent psychiatry direct relatively little attention to the issues surrounding adolescent addiction. The Clinical Handbook of Adolescent Addiction is one response to the challenge of meeting the mental health needs and behavior-related problems of addicted teenagers. The work has been edited as an independent project by members of the American Society for Adolescent Psychiatry, the oldest professional organization of psychiatrists devoted solely to the mental health care and treatment of teenagers in the USA. The forensic psychiatry perspective permeates the entire book. It will help to produce health providers with a deep and sensitive understanding of the developmental needs and behavior-related problems of adolescents. The Clinical Handbook of Adolescent Addiction is a practical tool for all those who help adolescents: practitioners of family medicine, general psychiatrists, child/adolescent psychiatrists, adolescent psychiatrists, addiction psychiatrists, non-psychiatric physicians specializing in addiction medicine, forensic psychiatrists, psychologists, clinical social workers, mental health administrators, Court/Probation/ Parole/Correctional health workers. The book is organized in a user-friendly format so that readers can easily locate the chapters that provide the information that is required. In some instances, topics of special importance deliberately have been addressed in more than one chapter, to illuminate the topics from a variety of vantage points. One aim of the editors is to move the topic from being a specialist area to a generalist one by providing tools for generalist to use.

Public Health Law Research: Theory and Methods definitively explores the mechanisms, theories and models central to public health law research – a growing field dedicated to measuring and studying law as a central means for advancing public health. Editors Alexander C. Wagenaar and Scott Burris outline integrated theory drawn from numerous disciplines in the social and behavioral sciences; specific mechanisms of legal effect and guidelines for collecting and coding empirical datasets of statutory and case law; optimal research designs for randomized trials and natural experiments for public health law evaluation; and methods for qualitative and cost-benefit studies of law.. They also discuss the challenge of effectively translating the results of scientific evaluations into public health laws and highlight the impact of this growing field. “How exactly the law can best be used as a tool for protecting and enhancing the public’s health has long been the subject of solely opinion and anecdote. Enter Public Health Law Research, a discipline designed to bring the bright light of science to the relationships between law and health. This book is a giant step forward in illuminating that subject.” – Stephen Teret, JD, MPH, Professor, Director, Center for Law and the Public's Health, Johns Hopkins Bloomberg School of Public Health “Wagenaar and Burris bring a dose of much needed rigor to the empirical study of which public health law interventions really matter, and which don’t.” – Bernard S. Black, JD, Chabraja Professor, Northwestern University Law School and Kellogg School of Management Companion Web site: www.josseybass.com/go/wagenaar

This book has been developed to help nurses who are in nurse practitioner roles by supporting them to develop their ‘advanced practice skills’. This book is intended to build on skills and knowledge that nurses will have acquired at staff nurse level. It is intended that this book will develop skills and knowledge which until recently have been more in the medical domain, such sexual history taking and physical assessment.

Cultural Competence in Health Education and Health Promotion, 2nd edition, examines the importance of ethnic and cultural factors for community health practice. Edited and written by a stellar list of contributors who are experts in field, this book describes essential theories, models, and practices for working with race, ethnicity, gender, and social issues. The authors cover a wide range of topics including demographics, disparities, complementary and alternative medicine, spiritually grounded approaches, multicultural populations, culturally competent needs assessment and planning, communication, workforce, program planning, aging, sexual orientation, and future challenges. This edition has substantially expanded coverage on working with diverse groups, social determinants of health, spirituality, theoretical models for multicultural populations, planning and program evaluation, and aging, with new content includes coverage of disability and health literacy. This edition also reflects the latest standards for Certified Health Education Specialist certification and national standards on Culturally and Linguistically Appropriate Services (CLAS), from Department of Health and Human Services, Office of Minority Health

Designing and Conducting Research in Health and Human Performance shows students how to become effective producers and consumers of health and human performance research. The book provides comprehensive coverage of both quantitative and qualitative research methods and includes step-by-step guidance for writing effective research proposals and theses. In addition, the authors show how to read, assess, interpret, and apply published research and how to conduct basic studies in health, physical education, exercise science, athletic training, and recreation. Designing and Conducting Research in Health and Human Performance is filled with illustrative examples that emphasize the real-world applications of research methods. Throughout, the authors draw on a variety of examples that were selected because they provide a context to further the understanding of health and human performance research. Research to Practice examples and Tips are included by the authors to help students better appreciate the book's content. These study aids provide suggestions and additional resources to assist students in understanding the research process. Key Terms, defined and highlighted, enrich each chapter. Chapter Review Questions, designed to help students comprehend and follow best practices in research methods, close each chapter. Online resources and guides developed by the authors to support and enhance students' learning of important research concepts are available.

Evidence-based practice is an idea whose time has come. Few concepts can have achieved the status of unchallengeable common sense in such a short space of time, and across such a broad range of professional activity. As yet there have been few opportunities to take stock and reflect on the evidence for evidence-based practice, or the implications of its adoption. How effective or feasible is it in medicine? Is it really different? What are the consequences of not basing practice on research? Can evidence-based practice be used in non-clinical settings, where practitioners must deal with the complexity of multi-problem individuals, families and organizations? This text introduces the key concept of Evidence-Based Practice and accounts for its emergence and rapid expansion within and beyond medicine. It then goes on to describe how evidence-based practice is being translated in key areas (medicine, nursing, mental health education and social welfare) while critically appraising the strengths and weaknesses of evidence-based practice as it applies in a range of fields of professional practice.

Developing Nursing Practice with Children and Young People explores the context of children’s nursing in light of recent policy changes, and looks at contemporary issues and emerging roles within the field. Divided into four parts, Part One focuses on the emergence of children’s nursing in healthcare, detailing events and developments that have shaped the role of children’s nurses. Part Two examines many aspects of practice for registered practitioners in nursing, ranging from acute care settings to children’s nurses’ developing roles in primary care, mental health and with children and young people with special health and social needs. Part Three then provides a detailed analysis of advanced practice in children’s nursing. The advanced skills portfolio is presented in depth, augmented by exemplars of a number of advanced practice roles which have already been established. Finally, Part Four builds on the previous three parts by offering several case studies from practice – including accounts from children, young people and families, as well as assistant practitioners and student nurses. The text concludes by focusing on the longer term scope for children’s nurses.

Mental health is a significant factor in providing effective nursing care for patients in hospital and residential settings. Non-mental health nursing staff often lack the confidence, knowledge and skills to effectively meet the mental health needs of patients who are experiencing psychiatric problems and psychological distress. Mental Health Care for Nurses: Applying mental health skills in the general hospital provides a step-by-step guide which will help nurses identify these needs and address them in practice. The first part of Mental Health Care for Nurses: Applying mental health skills in the general hospital explores the context of mental health care in hospital and residential settings and provides a practical framework for assessment, planning and delivery of mental health care. The second part explores specific topics such as self-harm and suicide prevention, caring for the patient displaying challenging behaviour, maternal and perinatal mental health problems, mental health problems associated with old age, mood disorders, and illicit drug and alcohol dependence.

A total CBT training solution, with practical strategies for improving educational outcomes. Teaching and Supervising Cognitive Behavioral Therapy is the first comprehensive package to provide empirically-validated CBT training and supervisory techniques. Applicable to a variety of behavioral health care disciplines, this multi-modal guide provides educators with the information and tools that can help improve educational outcomes. An examination of CBT developments over the past twenty years leads into a discussion of practical applications for improving CBT education, while addressing the technological advances that facilitate dissemination and the specific challenges posed to confidentiality and patient care. The digital component contains additional audio and video content, plus downloadable worksheets that reinforce and expand upon the strategies presented. Coverage includes advice geared specifically toward the most commonly-encountered problems, with video of training sessions that address issues like frustration with patients, disbelief in psychotherapy, dislike of the method, and lack of skills. Readers will gain insight into effective goal setting, and implement a structured approach to supervision. Examine existing literature and research on training, supervision, and evaluation Integrate theory with practical strategies to improve learning outcomes Customize training approaches to specifically suit different professional groups Fit the methods to the environment, including workshops, webinars, and podcasts Mental health professionals who favor an empirically-based approach to therapy will appreciate the effectiveness of an empirically-based approach to pedagogy. Backed by over two decades of CBT research and the insight of leading CBT experts, Teaching and Supervising Cognitive Behavioral Therapy provides trainers with the tools and information they need to improve therapist educational outcomes.

This book covers fully the unique needs of patients in a UK setting. Each high risk group has a chapter dedicated to specific pathophysiological nuances, exercise prescription and exercise delivery. In addition, other influences on exercise including medications, appliances etc. are covered. Each chapter is based on the latest and best evidence.

FULLY REVISED, COMPREHENSIVE, AND PRACTICAL Learning the Language of Addiction Counseling, Fourth Edition introduces counselors, social workers, and students to the field of addiction counseling and helps them acquire the knowledge and develop the skills needed to counsel individuals who are caught in the destructive cycle of addiction. Drawing from her years of experience working in the addiction-counseling field, Geri Miller provides an engaging, balanced overview of the major theoretical foundations and clinical best practices in the field. Fully updated, the Fourth Edition offers a positive, practice-oriented counseling framework and features: A research-based, clinical application approach to addiction counseling that practitioners can turn to for fundamental, practical, clinical guidelines Revised chapters that reflect important changes in research and practice, including new DSMTM-5 criteria, new assessment instruments, and new and expanded treatments Case studies, interactive exercises, end-of-chapter questions, and other resources that facilitate the integration of knowledge into practice “Personal Reflections” sections at the beginning of each chapter provide an invaluable, unique perspective on the author’s evolving views of addiction counseling Updated and expanded online Instructor’s Manual that includes brief video clips, PowerPoint® slides, test bank questions for each chapter, and sample syllabi From assessment and diagnosis of addiction to preparing for certification and licensure as an addiction professional, this comprehensive book covers all of the essentials.

The focus of this book is on speech production and speech processing associated with cleft palate, covering phonetic (perceptual and instrumental), phonological and psycholinguistic perspectives, and including coverage of implications for literacy and education, as well as cross-linguistic differences. It draws together a group of international experts in the fields of cleft lip and palate and speech science to provide an up-to-date and in-depth account of the nature of speech production, and the processes and current evidence base of assessment and intervention for speech associated with cleft palate. The consequences of speech disorders associated with cleft on intelligibility and communicative participation are also covered. This book will provide a solid theoretical foundation and a valuable clinical resource for students of speech-language pathology, for practising speech-language pathologists, and for others interested in speech production in cleft palate, including researchers and members of multi-disciplinary cleft teams who wish to know more about the nature of speech difficulties associated with a cleft palate.

At last, a book about the little pieces of occupation which make up life' s real situations and experiences and form a basis for therapy. Offered in the form of stories about practice previously published in the popular US publication Advance for Occupational Therapy Practitioners, this enjoyable book presents occupational therapists as «masters of the mundane.» Therapists, students and educators will find this easy to read text a useful tool in guiding clinical approaches to therapy. Accompanied by theoretical papers by Dr. Estelle Breines and colleagues previously published in refereed international journals, these stories will aid the reader in understanding principles of active occupation that guide practice and shed light on how these ideas can be applied to the education of therapists.

With approximately 1 in 6 adults likely to experience a significant mental health problem at any one time (Office for National Statistics), research into effective interventions has never been more important. During the past decade there has been an increasing interest in the role that sport and physical activity can play in the treatment of mental health problems, and in mental health promotion. The benefits resulting from physiological changes during exercise are well documented, including improvement in mood and control of anxiety and depression. Research also suggests that socio-cultural and psychological changes arising from engagement in sport and physical activity carry valuable mental health benefits. Sport and Physical Activity for Mental Health is an evidence-based practical guide for nurses, allied health professionals, social workers, physical activity leaders, and sport coaches. The authors provide comprehensive analysis of a broad range of client narratives, integrating theory and the latest research to explore the effectiveness of various interventions. The book offers readers detailed recommendations, suggestions, and ideas as to how sport and physical activity opportunities can be tailored to provide the greatest mental health benefits.

'I can enthusiastically recommend the Manual of Clinical Paramedic Procedures as the book that I wish had been available to me when I was studying to become a paramedic.' From the foreword by Professor Malcolm Woollard, Chair, College of Paramedics; Professor in Pre-hospital and Emergency Care & Director, Pre-hospital, Emergency & Cardiovascular Care Applied Research Group, Coventry University Clinical procedures are a fundamental aspect of care for practitioners working in pre-hospital settings. The Manual of Clinical Paramedic Procedures is written specifically to support the practice of paramedics, ambulance technicians, first responders and volunteer ambulance personnel. It presents up-to-date, evidence-based expert knowledge, enabling paramedics to deliver effective, patient-focused care. This accessible handbook provides a comprehensive exploration of core competencies and skills, looking at topics including Aseptic Technique, Airway Management, Assisted Ventilation, Cardiopulmonary Resuscitation, Defibrillation and External Cardiac Pacing, Observations, Pain Assessment & Management, Respiratory Therapy, Spinal Management and Venepuncture. Each chapter provides the relevant anatomy & physiology, evidence-based rationales for each procedure, and contraindications of use. Key features: The first UK text to explore clinical procedures for paramedics With further reading and illustrations throughout All procedures include the rationale for the action recommended Guides paramedics in the clinical application of evidence-based procedures

Evidence-Based CBT is the first book to take an explicitly competencies-based approach to the cognitive-behavioural treatment of anxiety and depression in children and young people. It draws on top-name expertise to define and demonstrate the therapist competencies needed to effectively implement CBT.

Assessment and monitoring are fundamental aspects of the care of the acutely ill child, especially in high dependency areas and critical care units. Clinical Assessment and Monitoring in Children is a practical, introductory guide which provides detailed information on assessment and monitoring techniques, including physical assessment, physiological monitoring and an appraisal of additional assessment tools to enable practitioners to develop effective skills. The book adopts a physical systems approach, discusses assessment strategies and tools (starting with the least invasive and moving to the more complex) and examines how to analyse and apply the information to provide ongoing care. Each chapter explores physical assessment and examination whilst maintaining the focus on the child and the family. Clinical Assessment and Monitoring in Children assumes no prior knowledge, and provides the knowledge and skills needed to underpin decision-making and provide effective evidence-based care. This is an invaluable resource for all health care practitioners involved in caring for children. Key Features: • Explores assessment and monitoring of children from 0 – 16 years • Draws upon National Service Frameworks and clinical practice guidelines • Adopts a system by system approach • Provides knowledge and skills needed to underpin decision-making and provide effective evidence-based care • Includes hints on trouble-shooting and gaining the child and family’s co-operation • Includes case studies and suggested further reading

This hands-on guide addresses the present day realities of applying dialectical behavior therapy in a mental health and substance abuse recovery context. The book presents the DBT concept, Wise Mind, as adapted by author Andrew Bein, as central to a simple, powerful, empirically supported framework that respectfully engages clients in their own efforts to enhance personal well-being. The book includes empirically supported exercises with an emphasis on collaboration and client empowerment using a recovery oriented model for client treatment and improved outcomes.

Essential evidence-based strategies for the prevention and reduction of alcohol abuse among college students With contributions from notable substance abuse researchers, this practical guide presents clear strategies for prevention of and interventions for alcohol abuse in the college-age population. Ranging from community-based prevention programs to individual, motivational, and interview-based approaches, College Student Alcohol Abuse explores: The leading theories used to conceptualize college student drinking and related problems, with an emphasis on the clinical implications of each perspective Epidemiology of student drug use—including illicit drugs and nonmedical use of prescription drugs The spectrum of empirically supported prevention programs with a focus on best practices and materials How to conduct assessments and create intervention programs for students with substance abuse problems A must-have resource for every college administrator, resident staff member, and addiction counselor who works with this unique population, College Student Alcohol Abuse translates the latest research findings and interventions into clear and evidence-based strategies for assessing and treating college students who are abusing alcohol.

CBT for Anxiety Disorders presents a comprehensive overview of the latest anxiety disorder-specific treatment techniques contributed by the foremost experts in various CBT approaches. Summarizes the state-of-the-art CBT approaches for each of the DSM anxiety disorders Represents a one-stop tool for researchers, clinicians, and students on CBT for anxiety disorders Features world leading CBT authors who provide an up to date description of their respective treatment approaches in a succinct, and clinician-tailored, fashion

Guidance for addiction counselors in understanding and applying ethical standards Filled with proven strategies to help you examine your current practice for ethical snags and refresh your ethical thinking, Ethics for Addiction Professionals leads you in examining, building, and rebuilding aspects of your ethical practice with the goal of helping you become the strongest clinician possible—ethically speaking.Up-to-date and comprehensive, this practical guide examines real-life examples of ethical issues in clinical practice and illustrates potential pitfalls and the actions needed when faced with dilemmas. Helping addiction counselors learn how to deal with and apply ethical standards, Ethics for Addiction Professionals explores the gray area of common dilemmas and provides guidelines on how to determine the best course of action when the best course is unclear. Covers basic principles that affect current ethical concerns and dilemmas Includes illustrative real-world case studies Features well-defined professional codes of ethics Treats ethics as a set of guidelines designed to protect the client, the clinician, and the profession as a whole

Drawing on the experience of the National Institute for Health and Care Excellence (NICE), Achieving High Quality Care is a practical guide on how to recognise and implement high quality evidence and guidance. This new title provides an overview of the evidence behind successful initiatives designed to change practice and improve the quality of health care. It provides an overall picture of change management, from understanding the barriers to change to how these barriers can best be overcome. It presents a concise summary of the evidence for change, plus examples of specific initiatives drawn from experience of putting NICE guidance into practice. The book includes a wide range of examples of positive change – plus key practical points highlighted throughout the text – to help readers achieve improvements in patient care. Finally, it shows how to measure change, assess improvement to agreed standards and to manage the ongoing process of change towards improving health care. Achieving High Quality Care is a helpful guide for busy health care professionals wanting to improve services and patient care. It is relevant to everyone involved in the organisation and provision of quality health care, including clinicians and health care managers, who are trying to lead change and improve care through implementing evidence-based guidance.

The misuse of alcohol presents both individual physical and psychological problems as well as wider social consequences. Alcohol misuse is a frequent cause of attendance in accident and emergency departments and an underlying factor in a range of long term and chronic conditions commonly treated and managed within primary care settings. This expanded fifth edition includes new chapters on alcohol and the young person, alcohol related liver disease, neurological problems, alcohol and the older person, alcohol and cancer, and the alcohol nurse specialist. There is also improved coverage of the role of alcohol health workers, and guidance on the availability of voluntary alcohol services more generally, and the concluding resources chapter provides further guidance on how to access appropriate services. It incorporates current NICE guidelines, the Government’s Alcohol Strategy 2012, as well as case study scenarios and examples of best practice throughout. From a new editor and a multidisciplinary contributor team, ABC of Alcohol is a practical guide for general practitioners, family physicians, practice nurses, primary healthcare professionals as well as for junior doctors, medical and nursing students. This title is also available as a mobile App from MedHand Mobile Libraries. Buy it now from iTunes, Google Play or the MedHand store.

В основу учебника легли лекции, читаемые на кафедре химии Российского национального исследовательского медицинского университета им. Н. И. Пирогова. Применен интегрированный системный подход к учебному материалу, основанный на 18-групповой периодической системе химических элементов Д. И. Менделеева, рекомендованной к применению Международным союзом теоретической и прикладной химии ИЮПАК (IUPAС). Основные лабораторные практикумы с описанием рекомендуемых работ помогут будущим фармацевтам закрепить изученный материал практическими навыками.

В руководстве представлена методика эхокардиографического обследования детей и подростков. Отражен стандартный ход ультразвукового исследования сердца, описаны современные эхокардиографические технологии. Книга может служить пособием для самостоятельного обучения, а врач, уже владеющий эхокардиографией, найдет в ней полезный материал по частным вопросам ультразвукового исследования сердца при различной патологии. Руководство предназначено для детских кардиологов, врачей функциональной и ультразвуковой диагностики, а также для педиатров.