Animal Signaling and Function

Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network. • A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field. • Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases • Reviews the complex processes of signal integration and regulation • Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway’s role in diseases and potential clinical applications.

This first entry-level guide to the multifaceted field takes readers one step further than existing textbooks. In an easily accessible manner, the authors integrate the biochemistry, cell biology and medical implications of intracellular redox processes, demonstrating that complex science can be presented in a clear and almost entertaining way. Perfect for students and junior researchers, this is an equally valuable addition to courses in biochemistry, molecular biology, cell biology, and human physiology.

This extensively updated second edition of LTE Signaling, Troubleshooting and Performance Measurement describes the LTE signaling protocols and procedures for the third generation of mobile communications and beyond. It is one of the few books available that explain the LTE signaling messages, procedures and measurements down to the bit & byte level, and all trace examples are taken for a real lab and field trial traces. This book covers the crucial key performance indicators (KPI) to be measured during field trials and deployment phase of new LTE networks. It describes how statistic values can be aggregated and evaluated, and how the network can be optimized during the first stages of deployment, using dedicated examples to enhance understanding. Written by experts in the field of mobile communications, this book systematically describes the most recent LTE signaling procedures, explaining how to identify and troubleshoot abnormal network behavior and common failure causes, as well as describing the normal signaling procedures. This is a unique feature of the book, allowing readers to understand the root cause analysis of problems related to signaling procedures. This book will be especially useful for network operators and equipment manufacturers; engineers; technicians; network planners; developers; researchers; designers; testing personnel and project managers; consulting and training companies; standardization bodies.

Ciba Foundation Symposium 123 Antidepressants and Receptor Function Chairman: Dennis Murphy, 1986 Depression is a common and often debilitating affective disorder. Attempts to develop effective antidepressants have a long history, but many questions remain about the mechanisms of action of such treatments and about the aetiology and pathophysiology of depression itself. Early observations centred attention on central monoamine systems, and animal studies suggested that changes in beta-adrenoceptor responsiveness were a common effect of antidepressant therapies. More recent research has encompassed many different central and peripheral receptors, time-dependent adaptational events at synapses, and the functional significance of changes in neurotransmitter systems in both humans and experimental animals. Such pharmacological studies aimed ultimately at elucidating the neurochemical basis of depression and of promoting new therapeutic approaches, provide the focus of this symposium volume. Many different methods of investigating the links between monoamine systems, depression and antidepressant treatments are described. Recent studies of receptors and of monoamine uptake sites in the brain and the periphery (e.g. in platelets and fibroblasts) are reviewed, with emphasis on alpha and beta adrenoceptors, [3H]imipramine-binding sites and serotonin receptors. The results of monitoring amine metabolites in cerebrospinal fluid and of measuring neuroendocrine, physiological and behavioural responses to pharmacological challenge are presented, providing information on monoaminergic function in depressed patients and experimental animals before, during and after treatment with antidepressant drugs or electroconvulsive shock. Genetic influences on receptor density are also discussed, as is the relevance to human depressive illness of animal models, including stress-induced behavioural depression in rats and responses to social stressors in rhesus monkeys. This book should be of interest to neuropharmacologists, psychopharmacologists, clinical pharmacologists, behavioural scientists, psychiatrists and neuroscientists.

This textbook focuses on the relationship between physical exercise and cognition, a very timely and important topic with major theoretical and practical implications for a number of areas including ageing, neurorehabilitation, depression and dementia. It brings together a wide range of analytical approaches and experimental results to provide a very useful overview and synthesis of this growing field of study. The book is divided into three parts: Part I covers the conceptual, theoretical and methodological underpinnings and issues. Part II focuses on advances in exercise and cognition research, with appropriate sub-sections on ‘acute’ and ‘chronic’ exercise and cognition. Part III presents an overview of the area and makes suggestions for the direction of future research. This text provides a cutting-edge examination of this increasingly important area written by leading experts from around the world. The book will prove invaluable to researchers and practitioners in a number of fields, including exercise science, cognitive science, neuroscience and clinical medicine. Key Features: Unique in-depth investigation of the relationship between physical exercise and brain function. Covers theoretical approaches and experimental results and includes chapters on the latest developments in research design. Examines the effects of both acute and chronic exercise on brain function. International list of contributors, who are leading researchers in their field.

The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Plant anatomy and physiology and a broad understanding of basic plant processes are of primary importance to a basic understanding of plant science. These areas serve as the first important building blocks in a variety of fields of study, including botany, plant biology, and horticulture. Structure and Function of Plants will serve as a text aimed at undergraduates in the plant sciences that will provide an accurate overview of complex plant processes as well as details essential to a basic understanding of plant anatomy and physiology. Presented in an engaging style with full-color illustrations, Structure and Function of Plants will appeal to undergraduates, faculty, extension faculty, and members of Master Gardener programs.

Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive – and how they can be turned into potent weapons against it – is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.

Guidance to help you grasp even the most complex network structures and signaling protocols The Second Edition of Signaling in Telecommunication Networks has been thoroughly updated, offering new chapters and sections that cover the most recent developments in signaling systems and procedures. This acclaimed book covers subscriber and network signaling in both fixed and mobile networks. Coverage begins with an introduction to circuit-switched telephone networks, including an examination of trunks, exchanges, access systems, transmission systems, and other basic components. Next, the authors introduce signaling concepts, beginning with older Channel Associated Signaling (CAS) systems and progressing to today's Common Channel Signaling (CCS) systems. The book then examines packet networks and their use in transmitting voice (VoIP), TCP/IP protocols, VoIP signaling protocols, and ATM protocols. Throughout the book, the authors emphasize functionality, particularly the roles of individual protocols and how they fit in network architectures, helping readers grasp even the most complex network structures and signaling protocols. Highlights of the Second Edition include: Coverage of the latest developments and topics, including new chapters on access networks, intelligent network application part, signaling for voice communication in packet networks, and ATM signaling Drawings and tables that help readers understand and visualize complex systems Comprehensive, updated references for further study Examples to help readers make the bridge from theory to application With the continued growth and expansion of the telecommunications industry, the Second Edition is essential reading for telecommunications students as well as anyone involved in this dynamic industry needing a solid understanding of the different signaling systems and how they work. Moreover, the book helps readers wade through the voluminous and complex technical standards by providing the essential structure, terminology, and functionality needed to understand them.

Domestic Animal Behavior for Veterinarians and Animal Scientists, Sixth Edition is a fully updated revision of this popular, classic text offering a thorough understanding of the normal behavior of domestic animals. Provides a complete understanding of the normal behavior of domestic animals Covers dogs, cats, horses, pigs, sheep, cattle, and goats Describes all key aspects of animal behavior, with images to support the concepts Revised and updated to cover the latest thinking, with enhanced coverage of behavioral genetics, animal cognition, and learning Includes access to a companion website with review questions and answers and the figures from the book in PowerPoint