Batch Effects and Noise in Microarray Experiments. Sources and Solutions

A classroom-tested book addressing key issues of electrical noise This book examines noise phenomena in linear and nonlinear high-frequency circuits from both qualitative and quantitative perspectives. The authors explore important noise mechanisms using equivalent sources and analytical and numerical methods. Readers learn how to manage electrical noise to improve the sensitivity and resolution of communication, navigation, measurement, and other electronic systems. Noise in High-Frequency Circuits and Oscillators has its origins in a university course taught by the authors. As a result, it is thoroughly classroom-tested and carefully structured to facilitate learning. Readers are given a solid foundation in the basics that allows them to proceed to more advanced and sophisticated themes such as computer-aided noise simulation of high-frequency circuits. Following a discussion of mathematical and system-oriented fundamentals, the book covers: * Noise of linear one- and two-ports * Measurement of noise parameters * Noise of diodes and transistors * Parametric circuits * Noise in nonlinear circuits * Noise in oscillators * Quantization noise Each chapter contains a set of numerical and analytical problems that enable readers to apply their newfound knowledge to real-world problems. Solutions are provided in the appendices. With their many years of classroom experience, the authors have designed a book that is ideal for graduate students in engineering and physics. It also addresses key issues and points to solutions for engineers working in the burgeoning satellite and wireless communications industries.

A comprehensive and versatile treatment of an important and complex topic in vehicle design Written by an expert in the field with over 30 years of NVH experience, Noise and Vibration Control of Automotive Body offers nine informative chapters on all of the core knowledge required for noise, vibration, and harshness engineers to do their job properly. It starts with an introduction to noise and vibration problems; transfer of structural-borne noise and airborne noise to interior body; key techniques for body noise and vibration control; and noise and vibration control during vehicle development. The book then goes on to cover all the noise and vibration issues relating to the automotive body, including: overall body structure; local body structure; sound package; excitations exerted on the body and transfer functions; wind noise; body sound quality; body squeak and rattle; and the vehicle development process for an automotive body. Vehicle noise and vibration is one of the most important attributes for modern vehicles, and it is extremely important to understand and solve NVH problems. Noise and Vibration Control of Automotive Body offers comprehensive coverage of automotive body noise and vibration analysis and control, making it an excellent guide for body design engineers and testing engineers. Covers all the noise and vibration issues relating to the automotive body Features a thorough set of tables, illustrations, photographs, and examples Introduces automotive body structure and noise and vibration problems Pulls together the diverse topics of body structure, sound package, sound quality, squeak and rattle, and target setting Noise and Vibration Control of Automotive Body is a valuable reference for engineers, designers, researchers, and graduate students in the fields of automotive body design and NVH.

Experiments in Holism: Theory and Practice in Contemporary Anthropologypresents a series of essays from leading anthropologists that critically reexamine the relevance of holism as a foundational tenet of anthropology, and its theoretical and methodological potential in today's world. Represents the first volume to consider the modern role of holism as a central anthropological concern across a wide range of anthropological traditions Critically examines the past and present predicament of holism and its potential for the renewal of future practice Features contributions from leading anthropologists which discuss how anthropology should be re-designed in the context of a changing world Challenges many of contemporary anthropology's central methods, theory, and functions

Praise for the First Edition “…extremely well written…a comprehensive and up-to-date overview of this important field.” – Journal of Environmental Quality Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition provides comprehensive coverage of recent advancements in microarray data analysis. A cutting-edge guide, the Second Edition demonstrates various methodologies for analyzing data in biomedical research and offers an overview of the modern techniques used in microarray technology to study patterns of gene activity. The new edition answers the need for an efficient outline of all phases of this revolutionary analytical technique, from preprocessing to the analysis stage. Utilizing research and experience from highly-qualified authors in fields of data analysis, Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition features: A new chapter on the interpretation of findings that includes a discussion of signatures and material on gene set analysis, including network analysis New topics of coverage including ABC clustering, biclustering, partial least squares, penalized methods, ensemble methods, and enriched ensemble methods Updated exercises to deepen knowledge of the presented material and provide readers with resources for further study The book is an ideal reference for scientists in biomedical and genomics research fields who analyze DNA microarrays and protein array data, as well as statisticians and bioinformatics practitioners. Exploration and Analysis of DNA Microarray and Other High-Dimensional Data, Second Edition is also a useful text for graduate-level courses on statistics, computational biology, and bioinformatics.

A practical introduction to microwave plasma for processing applications at a variety of pressures In Microwave Plasma Sources and Methods in Processing Technology , an award-winning team of researchers delivers a comprehensive introduction to microwaves and microwave-generated plasmas. Ideal for anyone interested in non-thermal gas discharge plasmas and their applications, the book includes detailed descriptions, explanations, and practical guidance for the study and use of microwave power, microwave components, plasma, and plasma generation. This reference includes over 130 full-color diagrams to illustrate the concepts discussed within. The distinguished authors discuss the plasmas generated at different levels of power, as well as their applications at reduced, atmospheric and higher pressures. They also describe plasmas inside liquids and plasma interactions with combustion flames. Microwave Plasma Sources and Methods in Processing Technology concludes with an incisive exploration of new trends in the study and application of microwave discharges, offering promising new areas of study. The book also includes: A thorough introduction to the basic principles of microwave techniques and power systems, including a history of the technology, microwave generators, waveguides, and wave propagation A comprehensive exploration of the fundamentals of the physics of gas discharge plasmas, including plasma generation, Townsend coefficients, and the Paschen curve Practical discussions of the interaction between plasmas and solid surfaces and gases, including PVD, PE CVD, oxidation, sputtering, evaporation, dry etching, surface activation, and cleaning In-depth examinations of microwave plasma systems for plasma processing at varied parameters Perfect for researchers and engineers in the microwave community, as well as those who work with plasma applications, Microwave Plasma Sources and Methods in Processing Technology will also earn a place in the libraries of graduate and PhD students studying engineering physics, microwave engineering, and plasmas.

Advances in methods of gear design and the possibility of predicting the sound pressure level and life time of gearboxes and perfect instrumentation of test stands allows for the production of a new generation of quiet transmission units. Current literature on gearbox noise and vibration is usually focused on a particular problem such as gearbox design without a detailed description of measurement methods for noise and vibration testing. Vehicle Gearbox Noise and Vibration: Measurement, Signal Analysis, Signal Processing and Noise Reduction Measures addresses this need and comprehensively covers the sources of noise and vibration in gearboxes and describes various methods of signal processing. It also covers gearing design, precision manufacturing, measuring the gear train transmission error, noise test on testing stands and also during vehicle pass-by tests. The analysis tools for gearbox inspection are based on the frequency and time domain methods, including envelope and average toothmesh analysis. To keep the radiated noise under control, the effect of load, the gear contact ratio and the tooth surface modification on noise and vibration are illustrated by measurement examples giving an idea how to reduce transmission noise. Key features: Covers methods of processing noise and vibration signals Takes a practical approach to the subject and includes a case study covering how to successfully reduce transmission noise Describes the procedure for the measurement and calculation of the angular vibrations of gears during rotation Considers various signal processing methods including order analysis, synchronous averaging, Vold-Kalman order tracking filtration and measuring the angular vibration Vehicle Gearbox Noise and Vibration: Measurement, Signal Analysis, Signal Processing and Noise Reduction Measures is a comprehensive reference for designers of gearing systems and test engineers in the automotive industry and is also a useful source of information for graduate students in automotive and noise engineering.

Covers experiment planning, execution, analysis, and reporting This single-source resource guides readers in planning and conducting credible experiments for engineering, science, industrial processes, agriculture, and business. The text takes experimenters all the way through conducting a high-impact experiment, from initial conception, through execution of the experiment, to a defensible final report. It prepares the reader to anticipate the choices faced during each stage.  Filled with real-world examples from engineering science and industry, Planning and Executing Credible Experiments: A Guidebook for Engineering, Science, Industrial Processes, Agriculture, and Business offers chapters that challenge experimenters at each stage of planning and execution and emphasizes uncertainty analysis as a design tool in addition to its role for reporting results. Tested over decades at Stanford University and internationally, the text employs two powerful, free, open-source software tools: GOSSET to optimize experiment design, and R for statistical computing and graphics. A website accompanies the text, providing additional resources and software downloads. A comprehensive guide to experiment planning, execution, and analysis Leads from initial conception, through the experiment’s launch, to final report Prepares the reader to anticipate the choices faced throughout an experiment Hones the motivating question Employs principles and techniques from Design of Experiments (DoE) Selects experiment designs to obtain the most information from fewer experimental runs Offers chapters that propose questions that an experimenter will need to ask and answer during each stage of planning and execution Demonstrates how uncertainty analysis guides and strengthens each stage Includes examples from real-life industrial experiments Accompanied by a website hosting open-source software Planning and Executing Credible Experiments is an excellent resource for graduates and senior undergraduates—as well as professionals—across a wide variety of engineering disciplines.

A comprehensive review of the science and engineering behind future propulsion systems and energy sources in sustainable aviation Future Propulsion Systems and Energy Sources: in sustainable aviation is a comprehensive reference that offers a review of the science and engineering principles that underpin the concepts of propulsion systems and energy sources in sustainable air transportation. The author – a noted expert in the field – examines the impact of air transportation on the environment and reviews alternative jet fuels, hybrid-electric and nuclear propulsion and power. He also explores modern propulsion for transonic and supersonic-hypersonic aircraft and the impact of propulsion on aircraft design. Climate change is the main driver for the new technology development in sustainable air transportation. The book contains critical review of gas turbine propulsion and aircraft aerodynamics; followed by an insightful presentation of the aviation impact on environment. Future fuels and energy sources are introduced in a separate chapter. Promising technologies in propulsion and energy sources are identified leading to pathways to sustainable aviation. To facilitate the utility of the subject, the book is accompanied by a website that contains illustrations, and equation files. This important book: Contains a comprehensive reference to the science and engineering behind propulsion and power in sustainable air transportation Examines the impact of air transportation on the environment Covers alternative jet fuels and hybrid-electric propulsion and power Discusses modern propulsion for transonic, supersonic and hypersonic aircraft Examines the impact of propulsion system integration on aircraft design Written for engineers, graduate and senior undergraduate students in mechanical and aerospace engineering, Future Propulsion Systems and Energy Sources: in sustainable aviation explores the future of aviation with a guide to sustainable air transportation that includes alternative jet fuels, hybrid-electric propulsion, all-electric and nuclear propulsion.

The first one-volume guide to sources of contamination in pharmaceuticals and medical devices Most books dealing with contaminants in medicinal products often focus on analytical methods for detecting nonspecific impurities. Key to the work of the pharmaceutical chemist, this unique reference helps identify the sources of contamination in medicinal and pharmaceutical products and medical devices. Divided into three parts, Sources of Contamination in Medicinal Products and Medical Devices covers chemical, microbiological, and physical (particulate matter) contamination, including those originating from sterilization procedures. As compelling as a medical documentary, the book sheds light on how impurities and contaminants can enter the human body transported via a specific product or treatment. Focusing on only those medicinal products and medical devices that may lead to exposure to contaminants harmful to human health, the book offers a comprehensive, systematic look at the entire universe of medical contamination: Chemical contaminants including residual solvents, catalyst residuals, and genotoxic impurities in active pharmaceutical ingredients (APIs) Diagnostic imaging agents (i.e., radiopharmaceuticals and contrast agents) Microbiological and endotoxin contamination involving single and multiple dose products, medical devices, and biofilms Contamination from sterilization procedures, residuals from radiation sterilization, ionizing radiation on packaging materials and medical devices Medicinal gases and volatile anesthetics Biopharmaceuticals including recombinant DNA technology products Extractables and leachables from containers made of glass, plastics, and metal Each section of the book contains information on what contaminants could be expected in a particular product, and how they were generated and reached that product. With up-to-date regulatory guidelines for determining contamination, as well as methods for assessing, quantifying, avoiding and removing contaminants, Sources of Contamination in Medicinal Products and Medical Devices is essential to fully understanding the specific threats that undermine the safety of medicines and medical devices.

This book provides the reader with knowledge on a wide variety of radiation fields and their effects on the electronic devices and systems. The author covers faults and failures in ULSI devices induced by a wide variety of radiation fields, including electrons, alpha-rays, muons, gamma rays, neutrons and heavy ions. Readers will learn how to make numerical models from physical insights, to determine the kind of mathematical approaches that should be implemented to analyze radiation effects. A wide variety of prediction, detection, characterization and mitigation techniques against soft-errors are reviewed and discussed. The author shows how to model sophisticated radiation effects in condensed matter in order to quantify and control them, and explains how electronic systems including servers and routers are shut down due to environmental radiation. Provides an understanding of how electronic systems are shut down due to environmental radiation by constructing physical models and numerical algorithms Covers both terrestrial and avionic-level conditions Logically presented with each chapter explaining the background physics to the topic followed by various modelling techniques, and chapter summary Written by a widely-recognized authority in soft-errors in electronic devices Code samples available for download from the Companion Website This book is targeted at researchers and graduate students in nuclear and space radiation, semiconductor physics and electron devices, as well as other areas of applied physics modelling. Researchers and students interested in how a variety of physical phenomena can be modelled and numerically treated will also find this book to present helpful methods.