Logistic Optimization of Chemical Production Processes

This is the first book dedicated to the entire field of integrated chemical processes, covering process design, analysis, operation and control of these processes. Both the editors and authors are internationally recognized experts from different fields in industry and academia, and their contributions describe all aspects of intelligent integrations of chemical reactions and physical unit operations such as heat exchange, separational operations and mechanical unit operations. As a unique feature, the book also introduces new concepts for treating different integration concepts on a generalized basis. Of great value to a broad audience of researchers and engineers from industry and academia.

While the choices of microbial and eukaryotic expression systems for production of recombinant proteins are many, most researchers in academic and industrial settings do not have ready access to pertinent biological and technical information since it is normally scattered throughout the scientific literature. This book closes the gap by providing information on the general biology of the host organism, a description of the expression platform, a methodological section – with strains, genetic elements, vectors and special methods, where applicable – as well as examples of proteins produced with the respective platform. The systems thus described are well balanced by the inclusion of three prokaryotes (two Gram-negatives and one Gram-positive), four yeasts, two filamentous fungi and two higher eukaryotic cell systems – mammalian and plant cells. Throughout, the book provides valuable practical and theoretical information on the criteria and schemes for selecting the appropriate expression platform, the possibility and practicality of a universal expression vector, and on comparative industrial-scale fermentation, with the production of a recombinant Hepatitis B vaccine chosen as an industrial example. With a foreword by Herbert P. Schweizer, Colorado State University, USA: «As a whole, this book is a valuable and overdue resource for a varied audience. It is a practical guide for academic and industrial researchers who are confronted with the design of the most suitable expression platform for their favorite protein for technical or pharmaceutical purposes. In addition, the book is also a valuable study resource for professors and students in the fields of applied biology and biotechnology.»

This reference work provides a comprehensive insight into past developments in the application of non-linear dynamics, such as production systems in the manufacturing and process engineering, mechanical engineering and plant construction and automation technology. As such, it is the first publication to document the successful implementation of non-linear dynamics into current tasks or problems of engineering thus far unsolved. The interdisciplinary team of contributors from research and industry establishes ties between mechanical methods of manufacturing and new methods reaching the dynamics of production lines and complete production systems.

Many different chemical processes take place inside solids or at solid surfaces and interfaces. However, their quantitative description sometimes seems difficult to understand. This book by Professor Schmalzried, author of the eminently successful Solid State Reactions; bridges the gap between the 'physical' and 'chemical' approaches to this subject because it is written in a language which both sides understand. For the first time, a comprehensive coverage of the rapidly developing field of Solid State Kinetics is available. The topics covered in this book go far beyond diffusional transport. Homogeneous and heterogeneous solid-state reactions, phase transitions or the influence of external fields are also treated in detail. With this background, the author explains e.g. charge transport mechanisms in ionic conductors, principles of sensor technology, or oxidation processes clearly and comprehensibly. This book is a must for every solid-state chemist and an indispensable tool for academic and industrial readers alike. From reviews: 'a first-rate reference work that a must for any science library' (J. Am Chem. Soc.) 'can be recommended without restrictions …' (Z. Phys. Chem.)

Combinatorial optimization is a multidisciplinary scientific area, lying in the interface of three major scientific domains: mathematics, theoretical computer science and management. The three volumes of the Combinatorial Optimization series aim to cover a wide range of topics in this area. These topics also deal with fundamental notions and approaches as with several classical applications of combinatorial optimization. Concepts of Combinatorial Optimization, is divided into three parts: – On the complexity of combinatorial optimization problems, presenting basics about worst-case and randomized complexity; – Classical solution methods, presenting the two most-known methods for solving hard combinatorial optimization problems, that are Branch-and-Bound and Dynamic Programming; – Elements from mathematical programming, presenting fundamentals from mathematical programming based methods that are in the heart of Operations Research since the origins of this field.

Chemical Physics of Food Edited by Peter Belton Based on the principle that food science requires the same rigour as the more traditional physical sciences, Professor Peter Belton has drawn together an international team of authors to demonstrate the chemical physics approach to food. Combining the applications of chemical and physical methods together with a clear quantitative consideration of data, The Chemical Physics of Food offers the food scientist and technologist: • Coverage of major materials, including starch and gluten • Consistent approach to the subject matter from a chemical physics viewpoint • An esteemed team of international Authors All those involved in research into food structure, including food scientists, food technologists, food chemists and physicists should find much of interest in this book which will also provide libraries in all universities, research establishments and food companies with a valuable reference for this important area. About the Editor Professor Peter Belton is based in the School of Chemical Sciences and Pharmacy at the University of East Anglia, Norwich, UK

HANDBOOK OF INTELLIGENT COMPUTING AND OPTIMIZATION FOR SUSTAINABLE DEVELOPMENT This book provides a comprehensive overview of the latest breakthroughs and recent progress in sustainable intelligent computing technologies, applications, and optimization techniques across various industries. Optimization has received enormous attention along with the rapidly increasing use of communication technology and the development of user-friendly software and artificial intelligence. In almost all human activities, there is a desire to deliver the highest possible results with the least amount of effort. Moreover, optimization is a very well-known area with a vast number of applications, from route finding problems to medical treatment, construction, finance, accounting, engineering, and maintenance schedules in plants. As far as optimization of real-world problems is concerned, understanding the nature of the problem and grouping it in a proper class may help the designer employ proper techniques which can solve the problem efficiently. Many intelligent optimization techniques can find optimal solutions without the use of objective function and are less prone to local conditions. The 41 chapters comprising the Handbook of Intelligent Computing and Optimization for Sustainable Development by subject specialists, represent diverse disciplines such as mathematics and computer science, electrical and electronics engineering, neuroscience and cognitive sciences, medicine, and social sciences, and provide the reader with an integrated understanding of the importance that intelligent computing has in the sustainable development of current societies. It discusses the emerging research exploring the theoretical and practical aspects of successfully implementing new and innovative intelligent techniques in a variety of sectors, including IoT, manufacturing, optimization, and healthcare. Audience It is a pivotal reference source for IT specialists, industry professionals, managers, executives, researchers, scientists, and engineers seeking current research in emerging perspectives in the field of artificial intelligence in the areas of Internet of Things, renewable energy, optimization, and smart cities.

While existing books related to DOE are focused either on process or mixture factors or analyze specific tools from DOE science, this text is structured both horizontally and vertically, covering the three most common objectives of any experimental research: * screening designs * mathematical modeling, and * optimization. Written in a simple and lively manner and backed by current chemical product studies from all around the world, the book elucidates basic concepts of statistical methods, experiment design and optimization techniques as applied to chemistry and chemical engineering. Throughout, the focus is on unifying the theory and methodology of optimization with well-known statistical and experimental methods. The author draws on his own experience in research and development, resulting in a work that will assist students, scientists and engineers in using the concepts covered here in seeking optimum conditions for a chemical system or process. With 441 tables, 250 diagrams, as well as 200 examples drawn from current chemical product studies, this is an invaluable and convenient source of information for all those involved in process optimization.

Since carbohydrate oligomers are still a challenge in synthetic chemistry, this book on recent developments fulfils a great need. Covering the chemistry necessary to synthesize exact copies of these structures, top authors from all around the world comprehensively deal with synthesis from anomeric halides, from miscellaneous glycosyl donors, and by indirect and special methods, as well as 1-oxygen-and 1-sulfur-substituted derivatives. They demonstrate the best approach for the stereoselective formation of the intermonomeric bond, making this essential reading for every biochemist working in biosynthesis, the exploration of biopathways and vaccines.

Agglomeration is integral to the processes of modification of powders, production of composites and creation of new materials which are required in pharmaceuticals, foods, chemicals, fertilizers and agrochemicals, minerals, ceramics, metallurgy and all material producing industries. The binding mechanisms and the particle behavior as well as the characteristics of the processes and the resulting agglomerates are the same whether they are occuring in the 'ultra-clean' pharmaceutical or food industries or in 'dirty' minerals or waste processing plants. The book introduces the interdisciplinary approach to the development of new concepts and the solution of problems. It is a complete and up-to-date practical guide describing the various agglomeration phenomena and industrial techniques for size enlargement. In addition to introducing the properties of agglomerates and the characteristics of the different methods, descriptions of the machinery and discussions of specific equipment features are the main topics. The detailed evaluation of the subject is based on the authors experience as student, researcher, teacher, developer, designer, vendor, and user as well as expert and consultant in the field of agglomeration, its technologies and products, and is complemented by the know-how of colleagues who are active in specific areas and information from vendors. It is intended for everybody working in industries that process and handle particulate solids as it aims to help understand and control unwanted agglomeration as well as use, improve, and develop methods for the beneficial size enlargement by agglomeration.