Proteomic Applications in Cancer Detection and Discovery

Fundamentals of Cancer Detection, Treatment, and Prevention The professional guide to cancer diagnosis and therapy for researchers and clinicians In Fundamentals of Cancer Detection, Treatment, and Prevention, distinguished researcher Surya K. De delivers a concise and authoritative guide to cancer treatment, diagnosis, and prevention. The book offers a comprehensive overview of cancer in humans, from its causes, symptoms, and diagnosis to the variety of treatment options available today. Intuitively organized by cancer type, this guide provides concise information on risk factors, diagnosis, and treatment options for all commonly encountered tumors, including surgery, radiation therapy, chemotherapy, and immunotherapy. All US FDA-approved drugs—like small molecules, peptides, monoclonal antibodies, whole antibodies, gene therapy, antibody-drug conjugates, and cell therapies—are considered, and information about their generic and brand names, clinical uses, and mechanisms of action is presented. Readers will also find: A thorough overview of human cancers, including cancer risk factors and possible preventions Comprehensive explorations of bladder, blood, brain, and spinal cord cancers Practical discussions of breast, colorectal, cervical, kidney, and liver cancer In-depth examinations of lung, skin, ovarian, vaginal, vulvar, pancreatic, and prostate cancers, as well as mesothelioma Perfect for pharmaceutical chemists, oncologists, pharmacologists, and medicinal chemists, Fundamentals of Cancer Detection, Treatment, and Prevention is an indispensable guide for professional researchers, whether they are working in the clinic or the pharmaceutical industry.

A powerful new tool for all forensic accountants, or anyone who analyzes data that may have been altered Benford's Law gives the expected patterns of the digits in the numbers in tabulated data such as town and city populations or Madoff's fictitious portfolio returns. Those digits, in unaltered data, will not occur in equal proportions; there is a large bias towards the lower digits, so much so that nearly one-half of all numbers are expected to start with the digits 1 or 2. These patterns were originally discovered by physicist Frank Benford in the early 1930s, and have since been found to apply to all tabulated data. Mark J. Nigrini has been a pioneer in applying Benford's Law to auditing and forensic accounting, even before his groundbreaking 1999 Journal of Accountancy article introducing this useful tool to the accounting world. In Benford's Law, Nigrini shows the widespread applicability of Benford's Law and its practical uses to detect fraud, errors, and other anomalies. Explores primary, associated, and advanced tests, all described with data sets that include corporate payments data and election data Includes ten fraud detection studies, including vendor fraud, payroll fraud, due diligence when purchasing a business, and tax evasion Covers financial statement fraud, with data from Enron, AIG, and companies that were the target of hedge fund short sales Looks at how to detect Ponzi schemes, including data on Madoff, Waxenberg, and more Examines many other applications, from the Clinton tax returns and the charitable gifts of Lehman Brothers to tax evasion and number invention Benford's Law has 250 figures and uses 50 interesting authentic and fraudulent real-world data sets to explain both theory and practice, and concludes with an agenda and directions for future research. The companion website adds additional information and resources.

Object detection, tracking and recognition in images are key problems in computer vision. This book provides the reader with a balanced treatment between the theory and practice of selected methods in these areas to make the book accessible to a range of researchers, engineers, developers and postgraduate students working in computer vision and related fields. Key features: Explains the main theoretical ideas behind each method (which are augmented with a rigorous mathematical derivation of the formulas), their implementation (in C++) and demonstrated working in real applications. Places an emphasis on tensor and statistical based approaches within object detection and recognition. Provides an overview of image clustering and classification methods which includes subspace and kernel based processing, mean shift and Kalman filter, neural networks, and k-means methods. Contains numerous case study examples of mainly automotive applications. Includes a companion website hosting full C++ implementation, of topics presented in the book as a software library, and an accompanying manual to the software platform.

Much has changed since the first book Paediatric Oncology: Acute Nursing Care (1999), therefore, this new edition encompasses these changes in relation to the practice itself and the evidence that underpins it. Emphasis is placed on ensuring terminology is accurate, in keeping with the language of the current day. The book is divided into six sections: Chemotherapy, Haematopoetic Stem Cell Transplantation, General Surgery, Radiotherapy, Late Effects of cancer therapies, and Palliative Care. There is a brief commentary at the end of each section/chapter by a ‘novice’ author but experienced practitioner, highlighting to the reader what is already known and what the section/chapter adds to their current knowledge and practice.

This book focuses on the drug discovery and development applications of transition metal catalyzed processes, which can efficiently create preclinical and clinical drug candidates as well as marketed drugs. The authors pay particular attention to the challenges of transitioning academically-developed reactions into scalable industrial processes. Additionally, the book lays the groundwork for how continued development of transition metal catalyzed processes can deliver new drug candidates. This work provides a unique perspective on the applications of transition metal catalysis in drug discovery and development – it is a guide, a historical prospective, a practical compendium, and a source of future direction for the field.

A key resource and framework for assessing the performance of competing entities, including forecasting models Advances in DEA Theory and Applications provides a much-needed framework for assessing the performance of competing entities with special emphasis on forecasting models. It helps readers to determine the most appropriate methodology in order to make the most accurate decisions for implementation. Written by a noted expert in the field, this text provides a review of the latest advances in DEA theory and applications to the field of forecasting. Designed for use by anyone involved in research in the field of forecasting or in another application area where forecasting drives decision making, this text can be applied to a wide range of contexts, including education, health care, banking, armed forces, auditing, market research, retail outlets, organizational effectiveness, transportation, public housing, and manufacturing. This vital resource: Explores the latest developments in DEA frameworks for the performance evaluation of entities such as public or private organizational branches or departments, economic sectors, technologies, and stocks Presents a novel area of application for DEA; namely, the performance evaluation of forecasting models Promotes the use of DEA to assess the performance of forecasting models in a wide area of applications Provides rich, detailed examples and case studies Advances in DEA Theory and Applications includes information on a balanced benchmarking tool that is designed to help organizations examine their assumptions about their productivity and performance.

A comprehensive guide to antenna design, manufacturing processes, antenna integration, and packaging Antenna-in-Package Technology and Applications  contains an introduction to the history of AiP technology. It explores antennas and packages, thermal analysis and design, as well as measurement setups and methods for AiP technology. The authors—well-known experts on the topic—explain why microstrip patch antennas are the most popular and describe the myriad constraints of packaging, such as electrical performance, thermo-mechanical reliability, compactness, manufacturability, and cost. The book includes information on how the choice of interconnects is governed by JEDEC for automatic assembly and describes low-temperature co-fired ceramic, high-density interconnects, fan-out wafer level packaging–based AiP, and 3D-printing-based AiP. The book includes a detailed discussion of the surface laminar circuit–based AiP designs for large-scale mm-wave phased arrays for 94-GHz imagers and 28-GHz 5G New Radios. Additionally, the book includes information on 3D AiP for sensor nodes, near-field wireless power transfer, and IoT applications. This important book: • Includes a brief history of antenna-in-package technology • Describes package structures widely used in AiP, such as ball grid array (BGA) and quad flat no-leads (QFN) • Explores the concepts, materials and processes, designs, and verifications with special consideration for excellent electrical, mechanical, and thermal performance Written for students in electrical engineering, professors, researchers, and RF engineers,  Antenna-in-Package Technology and Applications  offers a guide to material selection for antennas and packages, antenna design with manufacturing processes and packaging constraints, antenna integration, and packaging.

Optics is a science which covers a very large domain and is experiencing indisputable growth. It has enabled the development of a considerable number of instruments, the optical component or methodology of which is often the essential part of portent systems. This book sets out show how optical physical phenomena such as lasers – the basis of instruments of measurement – are involved in the fields of biology and medicine. Optics in Instruments: Applications in Biology and Medicine details instruments and measurement systems using optical methods in the visible and near-infrared, as well as their applications in biology and medicine, through looking at confocal laser scanning microscopy, the basis of instruments performing in biological and medical analysis today, and flow cytometry, an instrument which measures at high speed the parameters of a cell passing in front of one or more laser beams. The authors also discuss optical coherence tomography (OCT), which is an optical imaging technique using non-contact infrared light, the therapeutic applications of lasers, where they are used for analysis and care, and the major contributions of plasmon propagation in the field of life sciences through instrumental developments, focusing on propagating surface plasmons (PSP) and localized plasmons (LP). Contents: 1. Confocal Laser Scanning Microscopy, Thomas Olivier and Baptiste Moine. 2. Flow Cytometry (FCM) Measurement of Cells in Suspension, Odile Sabido. 3. Optical Coherence Tomography, Claude Boccara and Arnaud Dubois. 4. Therapeutic Applications of Lasers, Genevi?ve Bourg-Heckly and Serge Mordon. 5. Plasmonics, Emmanuel Fort. About the Authors Jean-Pierre Goure is Emeritus Professor of optics at Jean Monnet University in Saint-Etienne, France, and was previously director of the UMR 5516 laboratory linked with CNRS. He is the author of more than 100 publications in various fields, such as spectroscopy, instrumentation, sensors, optical fiber and optical communications. He was also previously deputy director in engineering science at CNRS and a member of several scientific associations such as the French Optical Society and the European Optical Society.

Optics is a science which covers a very large domain and is experiencing indisputable growth. It has enabled the development of a considerable number of instruments, the optical component or methodology of which is often the essential part of portent systems. This book sets out show how optical physical phenomena such as lasers – the basis of instruments of measurement – are involved in the fields of biology and medicine. Optics in Instruments: Applications in Biology and Medicine details instruments and measurement systems using optical methods in the visible and near-infrared, as well as their applications in biology and medicine, through looking at confocal laser scanning microscopy, the basis of instruments performing in biological and medical analysis today, and flow cytometry, an instrument which measures at high speed the parameters of a cell passing in front of one or more laser beams. The authors also discuss optical coherence tomography (OCT), which is an optical imaging technique using non-contact infrared light, the therapeutic applications of lasers, where they are used for analysis and care, and the major contributions of plasmon propagation in the field of life sciences through instrumental developments, focusing on propagating surface plasmons (PSP) and localized plasmons (LP). Contents: 1. Confocal Laser Scanning Microscopy, Thomas Olivier and Baptiste Moine. 2. Flow Cytometry (FCM) Measurement of Cells in Suspension, Odile Sabido. 3. Optical Coherence Tomography, Claude Boccara and Arnaud Dubois. 4. Therapeutic Applications of Lasers, Genevi?ve Bourg-Heckly and Serge Mordon. 5. Plasmonics, Emmanuel Fort. About the Authors Jean-Pierre Goure is Emeritus Professor of optics at Jean Monnet University in Saint-Etienne, France, and was previously director of the UMR 5516 laboratory linked with CNRS. He is the author of more than 100 publications in various fields, such as spectroscopy, instrumentation, sensors, optical fiber and optical communications. He was also previously deputy director in engineering science at CNRS and a member of several scientific associations such as the French Optical Society and the European Optical Society.