Solid-Phase Synthesis and Combinatorial Technologies

Solid-phase synthesis of carbohydrates presents unique challenges to synthetic chemists and currently represents one of the hottest areas of research in bioorganic chemistry. Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries addresses the exciting expectation that solid-phase assembly of oligosaccharides will have a fundamental impact on the field of glycobiology. This publication details the methodologies currently investigated for the attachment of carbohydrates to beads, synthesis including coupling strategies, and removal of the product from beads. With chapters written by eminent contributing authors, the material explores different synthetic strategies, glycosylation protocols, the use of solid supports versus soluble polymeric supports, and «on-resin» analytical methods. Tremendous progress in the field has set the stage for Solid Support Oligosaccharide Synthesis and Combinatorial Carbohydrate Libraries to provide a wealth of information on such topics as: Specific oligosaccharide structures used in signal transduction processes Preparation and screening of glycopeptide libraries Solid-phase carbohydrate synthesis

Solid-Phase Organic Synthesis Edited by Kevin Burgess, Texas A & M University Efficient, high-throughput chemistry is now the focus of many research laboratories. Solid-phase organic syntheses are central to many of these combinatorial and parallel screening methodologies. Consequently, they have been a major scientific theme of the 1990s and promise to remain prominent for the first part of the new millennium. Indeed, a bewildering number of papers have entered the literature on this topic; some report minor modifications enabling transformation of solution-phase methods to a solid support, while others report major innovations. Solid-Phase Organic Synthesis collects, highlights, and critiques some of the key developments in the field. Leading practitioners explain different perspectives on diverse aspects of the area. Specific topics covered include: Syntheses of guanidines Palladium-catalyzed C-C bond forming reactions S_nAr reactions for the formation of heterocycles Sequence-specific arylalkyne oligomers Resin-supported capture agents and other reagents Synthesis on pins Monitoring of supported reactions using IR Solid-phase syntheses of natural product derivatives Of related interest: Combinatorial Chemistry and Molecular Diversity in Drug Discovery, Eric M. Gordon and James F. Kerwin 1998 (0-471-15518-7) 544 pp. Combinatorial Chemistry Synthesis and Application, Stephen R. Wilson and Anthony W. Czarnik 1997 (0-471-12687-X) 288 pp.

Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments. Featuring chapters written by leading researchers in the field, Solid-Phase Organic Synthesis is divided into two parts: Part One, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to identify the presence of functional groups, combinatorial synthesis, and diversity-oriented synthesis. Readers will discover how solid-phase synthesis is currently used to facilitate the discovery of new molecular functionality. The final chapter discusses how using a support can change or increase reaction selectivity. Part Two, Applications, presents examples of the solid-phase synthesis of various classes of organic molecules. Chapters explore general asymmetric synthesis on a support, strategies for heterocyclic synthesis, and synthesis of radioactive organic molecules, dyes, dendrimers, and oligosaccharides. Each chapter ends with a set of conclusions that underscore the key concepts and methods. References in each chapter enable readers to investigate any topic in greater depth. With its presentation of basic concepts as well as recent findings and applications, Solid-Phase Organic Synthesis is the ideal starting point for students and researchers in organic, medicinal, and combinatorial chemistry who want to take full advantage of current solid-phase synthesis techniques.

Linker design is an expanding field with an exciting future in state-of-the-art organic synthesis. Ever-increasing numbers of ambitious solution phase reactions are being adapted for solid-phase organic chemistry and to accommodate them, large numbers of sophisticated linker units have been developed and are now routinely employed in solid-phase synthesis. Linker Strategies in Solid-Phase Organic Synthesis guides the reader through the evolution of linker units from their genesis in solid-supported peptide chemistry to the cutting edge diversity linker units that are defining a new era of solid phase synthesis. Individual linker classes are covered in easy to follow chapters written by international experts in their respective fields and offer a comprehensive guide to linker technology whilst simultaneously serving as a handbook of synthetic transformations now possible on solid supports. Topics include: the principles of solid phase organic synthesis electrophile and nucleophile cleavable linker units cyclative cleavage as a solid phase strategy photocleavable linker units safety-catch linker units enzyme cleavable linker units T1 and T2 –versatile triazene linker groups hydrazone linker units benzotriazole linker units phosphorus linker units sulfur linker units selenium and tellurium linker units sulfur, oxygen and selenium linker units cleaved by radical processes silicon and germanium linker units boron and stannane linker units bismuth linker units transition metal carbonyl linker units linkers releasing olefins or cycloolefins by ring-closing metathesis fluorous linker units solid-phase radiochemistry The book concludes with extensive linker selection tables, cataloguing the linker units described in this book according to the substrate liberated upon cleavage and conditions used to achieve such cleavage, enabling readers to choose the right linker unit for their synthesis. Linker Strategies in Solid-Phase Organic Synthesis is an essential guide to the diversity of linker units for organic chemists in academia and industry working in the broad areas of solid-phase organic synthesis and diversity oriented synthesis, medicinal chemists in the pharmaceutical industry who routinely employ solid-phase chemistry in the drug discovery business, and advanced undergraduates, postgraduates, and organic chemists with an interest in leading-edge developments in their field.

Phase lock loop frequency synthesis finds uses in a myriad of wireless applications – from local oscillators for receivers and transmitters to high performance RF test equipment. As the security and reliability of mobile communication transmissions have gained importance, PLL and frequency synthesisers have become increasingly topical subjects. Phase Lock Loops and Frequency Synthesis examines the various components that make up the phase lock loop design, including oscillators (crystal, voltage controlled), dividers and phase detectors. Interaction amongst the various components are also discussed. Real world problems such as power supply noise, shielding, grounding and isolation are given comprehensive coverage and solved examples with MATHCAD programs are presented throughout. Presents a comprehesive study of phase lock loops and frequency synthesis in communication systems Written by an internationally-recognised expert in the field Details the problem of spurious signals in PLL frequency synthesizers, a topic neglected by available competing titles Provides detailed theorectical background coupled with practical examples of state-of-the-art device design MATHCAD programs and simulation software to accompany the design exercises and examples This combination of thorough theoretical treatment and guidance on practical applications will appeal to mobile communication circuit designers and advanced electrical engineering students.

A concise, comprehensive introduction to the topic of statistical physics of combinatorial optimization, bringing together theoretical concepts and algorithms from computer science with analytical methods from physics. The result bridges the gap between statistical physics and combinatorial optimization, investigating problems taken from theoretical computing, such as the vertex-cover problem, with the concepts and methods of theoretical physics. The authors cover rapid developments and analytical methods that are both extremely complex and spread by word-of-mouth, providing all the necessary basics in required detail. Throughout, the algorithms are shown with examples and calculations, while the proofs are given in a way suitable for graduate students, post-docs, and researchers. Ideal for newcomers to this young, multidisciplinary field.

This is the fourth of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international «who's who» in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides The fourth volume in this series is structured in three main sections. The first section is about protection reactions and amino acid based peptidomimetics. The second, and most extensive, part is devoted to the medicinal chemistry of amino acids. It includes, among others, the chemistry of alpha- and beta amino acids, peptide drugs, and advances in N- and O-glycopeptide synthesis. The final part deals with amino acids in combinatorial synthesis. Methods, such as phage display, library peptide synthesis, and computational design are described. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

The first overview of this topic begins with some historical aspects and a survey of the principles of the gas aggregation method. The second part covers modifications of this method resulting in different specialized techniques, while the third discusses the post-growth treatment that can be applied to the nanoparticles. The whole is rounded off by a review of future perspectives and the challenges facing the scientific and industrial communities. An excellent resource for anyone working with the synthesis of nanoparticles, both in academia and industry.

Rave reviews for INTEGER AND COMBINATORIAL OPTIMIZATION «This book provides an excellent introduction and survey of traditional fields of combinatorial optimization . . . It is indeed one of the best and most complete texts on combinatorial optimization . . . available. [And] with more than 700 entries, [it] has quite an exhaustive reference list.»-Optima «A unifying approach to optimization problems is to formulate them like linear programming problems, while restricting some or all of the variables to the integers. This book is an encyclopedic resource for such formulations, as well as for understanding the structure of and solving the resulting integer programming problems.»-Computing Reviews «[This book] can serve as a basis for various graduate courses on discrete optimization as well as a reference book for researchers and practitioners.»-Mathematical Reviews «This comprehensive and wide-ranging book will undoubtedly become a standard reference book for all those in the field of combinatorial optimization.»-Bulletin of the London Mathematical Society «This text should be required reading for anybody who intends to do research in this area or even just to keep abreast of developments.»-Times Higher Education Supplement, London Also of interest . . . INTEGER PROGRAMMING Laurence A. Wolsey Comprehensive and self-contained, this intermediate-level guide to integer programming provides readers with clear, up-to-date explanations on why some problems are difficult to solve, how techniques can be reformulated to give better results, and how mixed integer programming systems can be used more effectively. 1998 (0-471-28366-5) 260 pp.

The latest frequency synthesis techniques, including sigma-delta, Diophantine, and all-digital Sigma-delta is a frequency synthesis technique that has risen in popularity over the past decade due to its intensely digital nature and its ability to promote miniaturization. A continuation of the popular Frequency Synthesis by Phase Lock, Second Edition, this timely resource provides a broad introduction to sigma-delta by pairing practical simulation results with cutting-edge research. Advanced Frequency Synthesis by Phase Lock discusses both sigma-delta and fractional-n—the still-in-use forerunner to sigma-delta—employing Simulink® models and detailed simulations of results to promote a deeper understanding. After a brief introduction, the book shows how spurs are produced at the synthesizer output by the basic process and different methods for overcoming them. It investigates how various defects in sigma-delta synthesis contribute to spurs or noise in the synthesized signal. Synthesizer configurations are analyzed, and it is revealed how to trade off the various noise sources by choosing loop parameters. Other sigma-delta synthesis architectures are then reviewed. The Simulink simulation models that provided data for the preceding discussions are described, providing guidance in making use of such models for further exploration. Next, another method for achieving wide loop bandwidth simultaneously with fine resolution—the Diophantine Frequency Synthesizer—is introduced. Operation at extreme bandwidths is also covered, further describing the analysis of synthesizers that push their bandwidths close to the sampling-frequency limit. Lastly, the book reviews a newly important technology that is poised to become widely used in high-production consumer electronics—all-digital frequency synthesis. Detailed appendices provide in-depth discussion on various stages of development, and many related resources are available for download, including Simulink models, MATLAB® scripts, spreadsheets, and executable programs. All these features make this authoritative reference ideal for electrical engineers who want to achieve an understanding of sigma-delta frequency synthesis and an awareness of the latest developments in the field.