Statistical Methods in Diagnostic Medicine

Praise for the First Edition « . . . the book is a valuable addition to the literature in the field, serving as a much-needed guide for both clinicians and advanced students.»—Zentralblatt MATH A new edition of the cutting-edge guide to diagnostic tests in medical research In recent years, a considerable amount of research has focused on evolving methods for designing and analyzing diagnostic accuracy studies. Statistical Methods in Diagnostic Medicine, Second Edition continues to provide a comprehensive approach to the topic, guiding readers through the necessary practices for understanding these studies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy and study design, the authors successfully define various measures of diagnostic accuracy, describe strategies for designing diagnostic accuracy studies, and present key statistical methods for estimating and comparing test accuracy. Topics new to the Second Edition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values and sample size calculations Correcting techniques for verification and imperfect standard biases Sample size calculation for multiple reader studies when pilot data are available Updated meta-analysis methods, now incorporating random effects Three case studies thoroughly showcase some of the questions and statistical issues that arise in diagnostic medicine, with all associated data provided in detailed appendices. A related web site features Fortran, SAS®, and R software packages so that readers can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is an excellent supplement for biostatistics courses at the graduate level. It also serves as a valuable reference for clinicians and researchers working in the fields of medicine, epidemiology, and biostatistics.

In recent years the number of innovative medicinal products and devices submitted and approved by regulatory bodies has declined dramatically. The medical product development process is no longer able to keep pace with increasing technologies, science and innovations and the goal is to develop new scientific and technical tools and to make product development processes more efficient and effective. Statistical Methods in Healthcare focuses on the application of statistical methodologies to evaluate promising alternatives and to optimize the performance and demonstrate the effectiveness of those that warrant pursuit is critical to success. Statistical methods used in planning, delivering and monitoring health care, as well as selected statistical aspects of the development and/or production of pharmaceuticals and medical devices are also addressed. With a focus on finding solutions to these challenges, this book: Provides a comprehensive, in-depth treatment of statistical methods in healthcare, along with a reference source for practitioners and specialists in health care and drug development. Offers a broad coverage of standards and established methods through leading edge techniques. Uses an integrated, case-study based approach, with focus on applications. Looks at the use of analytical and monitoring schemes to evaluate therapeutic performance. Features the application of modern quality management systems to clinical practice, and to pharmaceutical development and production processes. Addresses the use of modern Statistical methods such as Adaptive Design, Seamless Design, Data Mining, Bayesian networks and Bootstrapping that can be applied to support the challenging new vision. Practitioners in healthcare-related professions, ranging from clinical trials to care delivery to medical device design, as well as statistical researchers in the field, will benefit from this book.

Assessment Methods in Statistical Education: An International Perspective provides a modern, international perspective on assessing students of statistics in higher education. It is a collection of contributions written by some of the leading figures in statistical education from around the world, drawing on their personal teaching experience and educational research. The book reflects the wide variety of disciplines, such as business, psychology and the health sciences, which include statistics teaching and assessment. The authors acknowledge the increasingly important role of technology in assessment, whether it be using the internet for accessing information and data sources or using software to construct and manage individualised or online assessments. Key Features: Presents successful assessment strategies, striking a balance between formative and summative assessment, individual and group work, take-away assignments and supervised tests. Assesses statistical thinking by questioning students’ ability to interpret and communicate the results of their analysis. Relates assessment to the real world by basing it on real data in an appropriate context. Provides a range of individualised assessment methods, including those that deter plagiarism and collusion by providing each student with a unique problem to solve or dataset to analyse. This book is essential reading for anyone involved in teaching statistics at tertiary level or interested in statistical education research.

This new edition of a successful, bestselling book continues to provide you with practical information on the use of statistical methods for solving real-world problems in complex industrial environments. Complete with examples from the chemical and pharmaceutical laboratory and manufacturing areas, this thoroughly updated book clearly demonstrates how to obtain reliable results by choosing the most appropriate experimental design and data evaluation methods. Unlike other books on the subject, Statistical Methods in Analytical Chemistry, Second Edition presents and solves problems in the context of a comprehensive decision-making process under GMP rules: Would you recommend the destruction of a $100,000 batch of product if one of four repeat determinations barely fails the specification limit? How would you prevent this from happening in the first place? Are you sure the calculator you are using is telling the truth? To help you control these situations, the new edition: * Covers univariate, bivariate, and multivariate data * Features case studies from the pharmaceutical and chemical industries demonstrating typical problems analysts encounter and the techniques used to solve them * Offers information on ancillary techniques, including a short introduction to optimization, exploratory data analysis, smoothing and computer simulation, and recapitulation of error propagation * Boasts numerous Excel files and compiled Visual Basic programs-no statistical table lookups required! * Uses Monte Carlo simulation to illustrate the variability inherent in statistically indistinguishable data sets Statistical Methods in Analytical Chemistry, Second Edition is an excellent, one-of-a-kind resource for laboratory scientists and engineers and project managers who need to assess data reliability; QC staff, regulators, and customers who want to frame realistic requirements and specifications; as well as educators looking for real-life experiments and advanced students in chemistry and pharmaceutical science. From the reviews of Statistical Methods in Analytical Chemistry, First Edition: «This book is extremely valuable. The authors supply many very useful programs along with their source code. Thus, the user can check the authenticity of the result and gain a greater understanding of the algorithm from the code. It should be on the bookshelf of every analytical chemist.»-Applied Spectroscopy «The authors have compiled an interesting collection of data to illustrate the application of statistical methods . . . including calibrating, setting detection limits, analyzing ANOVA data, analyzing stability data, and determining the influence of error propagation.»-Clinical Chemistry «The examples are taken from a chemical/pharmaceutical environment, but serve as convenient vehicles for the discussion of when to use which test, and how to make sense out of the results. While practical use of statistics is the major concern, it is put into perspective, and the reader is urged to use plausibility checks.»-Journal of Chemical Education «The discussion of univariate statistical tests is one of the more thorough I have seen in this type of book . . . The treatment of linear regression is also thorough, and a complete set of equations for uncertainty in the results is presented . . . The bibliography is extensive and will serve as a valuable resource for those seeking more information on virtually any topic covered in the book.»-Journal of American Chemical Society "This book treats the application of statistics to analytical chemistry in a very practical manner. [It] integrates PC computing power, testing programs, and analytical know-how in the context of good manufacturing practice/good laboratory practice (GMP/GLP) . . .The book is of value in many fields of analytical chemistry and should be available in all r

Spatial epidemiology is the description and analysis of the geographical distribution of disease. It is more important now than ever, with modern threats such as bio-terrorism making such analysis even more complex. This second edition of Statistical Methods in Spatial Epidemiology is updated and expanded to offer a complete coverage of the analysis and application of spatial statistical methods. The book is divided into two main sections: Part 1 introduces basic definitions and terminology, along with map construction and some basic models. This is expanded upon in Part II by applying this knowledge to the fundamental problems within spatial epidemiology, such as disease mapping, ecological analysis, disease clustering, bio-terrorism, space-time analysis, surveillance and infectious disease modelling. Provides a comprehensive overview of the main statistical methods used in spatial epidemiology. Updated to include a new emphasis on bio-terrorism and disease surveillance. Emphasizes the importance of space-time modelling and outlines the practical application of the method. Discusses the wide range of software available for analyzing spatial data, including WinBUGS, SaTScan and R, and features an accompanying website hosting related software. Contains numerous data sets, each representing a different approach to the analysis, and provides an insight into various modelling techniques. This text is primarily aimed at medical statisticians, researchers and practitioners from public health and epidemiology. It is also suitable for postgraduate students of statistics and epidemiology, as well professionals working in government agencies.

This statistics textbook, with particular emphasis on radiation protection and dosimetry, deals with statistical solutions to problems inherent in health physics measurements and decision making. The authors begin with a description of our current understanding of the statistical nature of physical processes at the atomic level, including radioactive decay and interactions of radiation with matter. Examples are taken from problems encountered in health physics, and the material is presented such that health physicists and most other nuclear professionals will more readily understand the application of statistical principles in the familiar context of the examples. Problems are presented at the end of each chapter, with solutions to selected problems provided online. In addition, numerous worked examples are included throughout the text.

The explanation and implementation of statistical methods for the medical researcher or statistician remains an integral part of modern medical research. This book explains the use of experimental and analytical biostatistics systems. Its accessible style allows it to be used by the non-mathematician as a fundamental component of successful research. Since the third edition, there have been many developments in statistical techniques. The fourth edition provides the medical statistician with an accessible guide to these techniques and to reflect the extent of their usage in medical research. The new edition takes a much more comprehensive approach to its subject. There has been a radical reorganization of the text to improve the continuity and cohesion of the presentation and to extend the scope by covering many new ideas now being introduced into the analysis of medical research data. The authors have tried to maintain the modest level of mathematical exposition that characterized the earlier editions, essentially confining the mathematics to the statement of algebraic formulae rather than pursuing mathematical proofs. Received the Highly Commended Certificate in the Public Health Category of the 2002 BMA Books Competition.

This groundbreaking book introduces the application of statistical methodologies to e-Commerce data With the expanding presence of technology in today's economic market, the use of the Internet for buying, selling, and investing is growing more popular and public in nature. Statistical Methods in e-Commerce Research is the first book of its kind to focus on the statistical models and methods that are essential in order to analyze information from electronic-commerce (e-Commerce) transactions, identify the challenges that arise with new e-Commerce data structures, and discover new knowledge about consumer activity. This collection gathers over thirty researchers and practitioners from the fields of statistics, computer science, information systems, and marketing to discuss the growing use of statistical methods in e-Commerce research. From privacy protection to economic impact, the book first identifies the many obstacles that are encountered while collecting, cleaning, exploring, and analyzing e-Commerce data. Solutions to these problems are then suggested using established and newly developed statistical and data mining methods. Finally, a look into the future of this evolving area of study is provided through an in-depth discussion of the emerging methods for conducting e-Commerce research. Statistical Methods in e-Commerce Research successfully bridges the gap between statistics and e-Commerce, introducing a statistical approach to solving challenges that arise in the context of online transactions, while also introducing a wide range of e-Commerce applications and problems where novel statistical methodology is warranted. It is an ideal text for courses on e-Commerce at the upper-undergraduate and graduate levels and also serves as a valuable reference for researchers and analysts across a wide array of subject areas, including economics, marketing, and information systems who would like to gain a deeper understanding of the use of statistics in their work.

The promotion of standards and guidelines to advance quality assurance and control is an integral part of the health care sector. Quantitative methods are needed to monitor, control and improve the quality of medical processes. Statistical Development of Quality in Medicine presents the statistical concepts behind the application of industrial quality control methods. Filled with numerous case studies and worked examples, the text enables the reader to choose the relevant control chart, to critically apply it, improve it if necessary, and monitor its stability. Furthermore, the reader is provided with the necessary background to critically assess the literature on the application of control charts and risk adjustment and to apply the findings. Contains a user-friendly introduction, setting out the necessary statistical concepts used in the field. Uses numerous real-life case studies from the literature and the authors’ own research as the backbone of the text. Provides a supplementary website featuring problems and answers drawn from the book, alongside examples in Statgraphics. The accessible style of Statistical Development of in Clinical Medicine invites a large readership. It is primarily aimed at health care officials, and personnel responsible for developing and controlling the quality of health care services. However, it is also ideal for statisticians working with health care problems, diagnostic and pharmaceutical companies, and graduate students of quality control.

Statistical Methods in Customer Relationship Management focuses on the quantitative and modeling aspects of customer management strategies that lead to future firm profitability, with emphasis on developing an understanding of Customer Relationship Management (CRM) models as the guiding concept for profitable customer management. To understand and explore the functioning of CRM models, this book traces the management strategies throughout a customer’s tenure with a firm. Furthermore, the book explores in detail CRM models for customer acquisition, customer retention, customer acquisition and retention, customer churn, and customer win back. Statistical Methods in Customer Relationship Management: Provides an overview of a CRM system, introducing key concepts and metrics needed to understand and implement these models. Focuses on five CRM models: customer acquisition, customer retention, customer churn, and customer win back with supporting case studies. Explores each model in detail, from investigating the need for CRM models to looking at the future of the models. Presents models and concepts that span across the introductory, advanced, and specialist levels. Academics and practitioners involved in the area of CRM as well as instructors of applied statistics and quantitative marketing courses will benefit from this book.